Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
37 participants
INTERVENTIONAL
2016-05-31
2020-10-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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obese older aged, aged 65-85, BMI 30-40
Older aged patients who are obese and between the ages of 65-85 with a BMI between 30-40.
3-day diet Run-in
Participants will be studied on one occasion after a 3-day diet run-in. This will be followed by a breakfast meal.
fMRI
After a 3-day diet run-in, participants will undergo a functional magnetic resonance imaging procedure (fMRI). Repeat fMRI will be performed 30 minutes after the meal.
Intravenous catheter placed for blood draws
On the study day participants will present in the fasting state, have an intravenous catheter placed for blood draws and have baseline blood samples taken. Blood and appetite measures will be performed every half hour for 3 hours.
normal weight older aged, aged 65-85, BMI 18-25
Older aged patients who are of normal weight and between the ages of 65-85 with a BMI between 18-25.
3-day diet Run-in
Participants will be studied on one occasion after a 3-day diet run-in. This will be followed by a breakfast meal.
fMRI
After a 3-day diet run-in, participants will undergo a functional magnetic resonance imaging procedure (fMRI). Repeat fMRI will be performed 30 minutes after the meal.
Intravenous catheter placed for blood draws
On the study day participants will present in the fasting state, have an intravenous catheter placed for blood draws and have baseline blood samples taken. Blood and appetite measures will be performed every half hour for 3 hours.
obese younger aged, aged 21-45, BMI 30-40
Younger aged patients who are obese and between the ages of 21-45 with a BMI between 30-40 .
3-day diet Run-in
Participants will be studied on one occasion after a 3-day diet run-in. This will be followed by a breakfast meal.
fMRI
After a 3-day diet run-in, participants will undergo a functional magnetic resonance imaging procedure (fMRI). Repeat fMRI will be performed 30 minutes after the meal.
Intravenous catheter placed for blood draws
On the study day participants will present in the fasting state, have an intravenous catheter placed for blood draws and have baseline blood samples taken. Blood and appetite measures will be performed every half hour for 3 hours.
Interventions
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3-day diet Run-in
Participants will be studied on one occasion after a 3-day diet run-in. This will be followed by a breakfast meal.
fMRI
After a 3-day diet run-in, participants will undergo a functional magnetic resonance imaging procedure (fMRI). Repeat fMRI will be performed 30 minutes after the meal.
Intravenous catheter placed for blood draws
On the study day participants will present in the fasting state, have an intravenous catheter placed for blood draws and have baseline blood samples taken. Blood and appetite measures will be performed every half hour for 3 hours.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Younger adults (Y): 21-45
* Obese (Ob): body mass index (BMI) 30-40
* Normal Weight (NW): BMI 18-25
Exclusion Criteria
* Advanced organ failure;
* Active cancer diagnosis;
* Uncontrolled hypertension or metabolic disorder;
* Cognitive impairment or psychiatric disease limiting ability to comply;
* Presently in an exercise or diet program;
* Recent weight loss of \>5 lbs in past 6 mo.;
* Bariatric surgery;
* Use of any weight loss drugs;
* Use of any medication known to significantly affect appetite (anti-depressants are allowable);
* Present tobacco use;
* Use/abuse of substances of abuse including any marijuana use by history;
* Any contraindication to MRI;
* Claustrophobia;
* Body weight \>300 lbs; and
* Inability to fit in MRI scanner.
21 Years
85 Years
ALL
Yes
Sponsors
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University of Colorado, Denver
OTHER
Responsible Party
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Principal Investigators
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Marc-Andre Cornier, MD
Role: PRINCIPAL_INVESTIGATOR
University of Colorado, Denver
Locations
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Univeristy of Colorado
Aurora, Colorado, United States
Countries
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Other Identifiers
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15-1511
Identifier Type: -
Identifier Source: org_study_id
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