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Effects of Intense Exercise on Neural Responses to Food.

NCT ID: NCT01926431

Last Updated: 2013-08-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-09-30

Study Completion Date

2011-05-31

Brief Summary

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The primary aim of this study was to determine the effects of an acute bout of high intensity exercise on the brains response to viewing pictures of food using functional magnetic resonance imaging (fMRI).

Detailed Description

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It is clear that intense exercise impacts on peripheral appetite regulation, however very little is known about the impact of high-intensity exercise on central appetite regulation. This study aimed to investigate the effects of high-intensity exercise on both central and peripheral responses to images of food. Functional magnetic resonance techniques were used to assess the brains response to images of high and low calorie foods, following a short bout of high-intensity exercise. Appetite hormone concentrations were also measured. It was hypothesized that, due to the known effects of high-intensity exercise on appetite regulatory hormones and subjective appetite ratings, the activation of reward-related brain regions to visual food cues would be modulated following intense physical activity.

Conditions

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Neural Responses Appetite Hormones Subjective Appetite Sensations

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Exercise

60 minutes of high intensity treadmill running

Group Type EXPERIMENTAL

Exercise

Intervention Type OTHER

Rest

60 minutes of seated rest (control trial)

Group Type EXPERIMENTAL

Rest

Intervention Type OTHER

Interventions

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Exercise

Intervention Type OTHER

Rest

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Healthy, non-smokers, free from cardiovascular disease and metabolic disease, no medication, participated in moderate/vigorous physical activity (\>2 hours per week)

Exclusion Criteria

* Smokers, history of cardiovascular/metabolic disease, low physical activity levels, inability to participate in fMRI scanning sessions including contraindications to MRI
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Birmingham

OTHER

Sponsor Role lead

Responsible Party

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Daniel Crabtree

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Andrew Blannin, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Birmingham

Locations

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Birmingham University Imaging Centre

Birmingham, Midlands, United Kingdom

Site Status

Countries

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United Kingdom

References

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Crabtree DR, Chambers ES, Hardwick RM, Blannin AK. The effects of high-intensity exercise on neural responses to images of food. Am J Clin Nutr. 2014 Feb;99(2):258-67. doi: 10.3945/ajcn.113.071381. Epub 2013 Dec 4.

Reference Type DERIVED
PMID: 24305681 (View on PubMed)

Other Identifiers

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ERN_09-586

Identifier Type: REGISTRY

Identifier Source: secondary_id

fMRI Study

Identifier Type: -

Identifier Source: org_study_id