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The Effect of Oral Zinc Supplementation on Thiol Oxido-reductive Index

NCT ID: NCT02985905

Last Updated: 2016-12-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-07-31

Study Completion Date

2012-07-31

Brief Summary

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Although several studies have considered the relationship between infertility and semen thiol compounds levels, no study on the effects of asthenospermia treatments such as oral zinc supplementation on thiol related enzymes activity which are important in fertility of the individual has been reported.

Detailed Description

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The present study was conducted to study the effect of zinc supplementation on the quantitative and qualitative characteristics of semen along with reduced thiol, oxidized thiol and thiol related enzymes in the seminal plasma of asthenospermic patients.

Conditions

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Asthenozoospermia

Keywords

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Zinc supplementation Thiol Glutathione peroxidase Sulfhydryl oxidase

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Zinc sulfate

60 subfertile (age 32.5±3.23 year) men with asthenozoospermia was treated with zinc sulfate,every participant took two capsules of zinc sulfate per day for three months (each one 220 mg).

Group Type EXPERIMENTAL

zinc sulfate

Intervention Type DIETARY_SUPPLEMENT

The subfertile group treated with zinc sulfate, every participant took two capsules of zinc sulfate per day for three months (each one 220 mg).

Healthy control

60 fertile (age 31.6±3.3 year) men, no treatment

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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zinc sulfate

The subfertile group treated with zinc sulfate, every participant took two capsules of zinc sulfate per day for three months (each one 220 mg).

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* The presence of asthenozoospermia in the semen sample.

Exclusion Criteria

* The absence of endocrinopathy, varicocele, and female factor infertility. Smokers and alcoholic men were excluded from the study because of their recognized high seminal ROS levels and decreased antioxidant levels.
Minimum Eligible Age

26 Years

Maximum Eligible Age

36 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Ministry of Health, Iraq

NETWORK

Sponsor Role collaborator

mahmoud hussein hadwan

OTHER

Sponsor Role lead

Responsible Party

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mahmoud hussein hadwan

Principal Investigator

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Mahmoud Hadwan, PhD

Role: PRINCIPAL_INVESTIGATOR

Babylon University

L Almashhedy, PhD

Role: STUDY_DIRECTOR

Babylon University

Alsalman Abdulrrazaq, PhD

Role: STUDY_CHAIR

Babylon University

Locations

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Mahmoud Hadwan

Hillah, Babylon, Iraq

Site Status

Countries

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Iraq

References

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Alsalman ARS, Almashhedy LA, Hadwan MH. Effect of Oral Zinc Supplementation on the Thiol Oxido-Reductive Index and Thiol-Related Enzymes in Seminal Plasma and Spermatozoa of Iraqi Asthenospermic Patients. Biol Trace Elem Res. 2018 Aug;184(2):340-349. doi: 10.1007/s12011-017-1215-8. Epub 2017 Dec 8.

Reference Type DERIVED
PMID: 29222649 (View on PubMed)

Other Identifiers

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Babil-4

Identifier Type: -

Identifier Source: org_study_id