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Effect of Oral Zinc Sulfate Supplementation on Enzymes of Urate Pathway

NCT ID: NCT03361618

Last Updated: 2017-12-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-07-01

Study Completion Date

2012-06-01

Brief Summary

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Although many reports have investigated the relationship between subfertility and uric acid levels in semen, to the best of author knowledge, there is no study have been published to yet focus on the effects of asthenospermia treatments, such as given an oral zinc supplementation, on the activity of urate-related enzymes, which are important in fertility of human.

Detailed Description

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The present study was designed to investigate the effect of zinc supplementation on the qualitative and quantitative characteristics of semen, along with uric acid levels and urate-related enzymes in the seminal plasma and spermatozoa of asthenospermic males.

Conditions

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Infertility Unexplained

Keywords

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Uric acid Adenosine deaminase Zinc Sulfate 5'-nucleotidase Asthenospermia. Xanthine oxidase

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Semen volume after treatment.
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Zinc sulfate

60 subfertile (age 32.5±3.23 year) men with asthenozoospermia was treated with zinc sulfate, every participant took two capsules of zinc sulfate per day for three months (each one 220 mg).

Group Type EXPERIMENTAL

Zinc Sulfate

Intervention Type DIETARY_SUPPLEMENT

The subfertile group treated with zinc sulfate, every participant took two capsules of zinc sulfate per day for three months (each one 220 mg).

Healthy control

60 fertile (age 31.6±3.3 year) men, no treatment.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Zinc Sulfate

The subfertile group treated with zinc sulfate, every participant took two capsules of zinc sulfate per day for three months (each one 220 mg).

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* The presence of asthenozoospermia in the semen sample.
* Must be unable to reproduce.

Exclusion Criteria

* the absence of endocrinopathy, varicocele, and female factor infertility. Smokers and alcoholic men were excluded from the study because of their recognized high seminal ROS levels and decreased antioxidant levels.
Minimum Eligible Age

26 Years

Maximum Eligible Age

36 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Ministry of Health, Iraq

NETWORK

Sponsor Role collaborator

Babylon University

OTHER

Sponsor Role lead

Responsible Party

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mahmoud hussein hadwan

Principal Investigator Dr. Mahmoud Hussein Hadwan

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Abdul Razzaq A. Alsalman, PhD

Role: STUDY_CHAIR

University of Babyblon

Lamia A. Almashhedy, PhD

Role: STUDY_DIRECTOR

University of Babyblon

Mahmoud Hussein Hadwan, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Babyblon

Abdulsamie H Alta'ee, PhD

Role: STUDY_DIRECTOR

University of Babyblon

Locations

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Mahmoud Hussein Hadwan

Hillah, Babylon, Iraq

Site Status

Countries

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Iraq

References

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Alsalman ARS, Almashhedy LA, Alta'ee AH, Hadwan MH. Effect of Zinc Supplementation on Urate Pathway Enzymes in Spermatozoa and Seminal Plasma of Iraqi Asthenozoospermic Patients: A Randomized Controlled Trial. Int J Fertil Steril. 2020 Jan;13(4):315-323. doi: 10.22074/ijfs.2020.5760. Epub 2019 Nov 11.

Reference Type DERIVED
PMID: 31710193 (View on PubMed)

Other Identifiers

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Babil-5

Identifier Type: -

Identifier Source: org_study_id