Predictors of Unsuccessful Endoscopic Mucosal Resection of Complex Colon Polyps
NCT ID: NCT02782793
Last Updated: 2017-06-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
500 participants
OBSERVATIONAL
2014-08-31
2016-12-31
Brief Summary
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Detailed Description
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Most colon polyps are small and can be completely removed during a standard colonoscopy. However, there is a growing awareness amongst endoscopists of polyps that are too large or inaccessible to be safely removed during a routine colonoscopy. Previously, these lesions required surgery for removal of the affected part of the colon. There is a growing body of evidence that suggests these more complex colon polyps can be entirely removed endoscopically through a procedure called endoscopic mucosal resection (EMR), thereby avoiding costly and debilitating surgery. Given that it is a novel procedure, it is only available at specialized care centers.
EMR is a procedure identical to a colonoscopy, with more steps involved in the lifting and removal of complex polyps. As many as 80-90% of complex polyps can be successfully removed with EMR. However, it has been noted that removal of the polyp in pieces, rather than as a whole can result in a 20-30% recurrence rate at the resection site. Any manipulation of the polyp prior to EMR may impair the ability to fully remove the lesion. Some factors that have previously been suggested to increase the difficulty of EMR include previous dye injections, removal attempts, and polyp sampling. However, the true impact of previous manipulations of CCPs remains unclear.
This study aims to be one of the largest prospective, multi-centered studies investigating factors that predict the failure of EMR in the removal of complex colon polyps.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Patient's with complex colon polyps
Endoscopic Mucosal Resection
Interventions
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Endoscopic Mucosal Resection
Eligibility Criteria
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Inclusion Criteria
18 Years
90 Years
ALL
No
Sponsors
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University of Colorado, Denver
OTHER
H. Lee Moffitt Cancer Center and Research Institute
OTHER
University of California, Los Angeles
OTHER
M.D. Anderson Cancer Center
OTHER
Northwestern University
OTHER
Responsible Party
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Sri Komanduri
Director of Endoscopy
Locations
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UCLA Medical Center
Los Angeles, California, United States
University of Colorado, Denver
Denver, Colorado, United States
Moffitt Cancer Center
Tampa, Florida, United States
MD Anderson Cancer Center
Houston, Texas, United States
Countries
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Other Identifiers
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STU00095441
Identifier Type: -
Identifier Source: org_study_id
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