Anesthetic Effect on Immune Cell in Patients With Cancer
NCT ID: NCT02758249
Last Updated: 2018-01-25
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
47 participants
INTERVENTIONAL
2016-01-31
2016-01-31
Brief Summary
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The purpose of this study is to prove the variation of immune cell activity between preoperative and postoperative period.
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Detailed Description
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1. immediate before anesthesia induction
2. postoperative 1 hours
3. postoperative 24 hours
Immune cells isolation from patients peripheral blood mononuclear cells. Next, immune cell were co-culture with human cancer cell line (MCF-7) for 24 hours. investigation for immune cell or cancer cell survival by flow cytometry.
Conditions
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Study Design
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RANDOMIZED
FACTORIAL
BASIC_SCIENCE
SINGLE
Study Groups
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sevoflurane
patients under sevoflurane anesthesia
Sevoflurane
patients are anesthetized by using sevoflurane inhalation
propofol
patients under propofol anesthesia
propofol
patients are anesthetized by using propofol infusion
Interventions
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Sevoflurane
patients are anesthetized by using sevoflurane inhalation
propofol
patients are anesthetized by using propofol infusion
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* history of hypersensitivity reaction in propofol or sevoflurane
* history of previous cancer
* patient with ongoing inflammation
20 Years
FEMALE
No
Sponsors
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Konkuk University Medical Center
OTHER
Responsible Party
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Seong-Hyop Kim
Associate Professor
Principal Investigators
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Seong-Hyop Kim, M.D., Ph.D.
Role: PRINCIPAL_INVESTIGATOR
Konkuk University Medical Center
Locations
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Konkuk University Medical Center
Seoul, , South Korea
Countries
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References
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Lim JA, Oh CS, Yoon TG, Lee JY, Lee SH, Yoo YB, Yang JH, Kim SH. The effect of propofol and sevoflurane on cancer cell, natural killer cell, and cytotoxic T lymphocyte function in patients undergoing breast cancer surgery: an in vitro analysis. BMC Cancer. 2018 Feb 7;18(1):159. doi: 10.1186/s12885-018-4064-8.
Other Identifiers
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KUH1160098
Identifier Type: -
Identifier Source: org_study_id
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