Anesthesia and Cancer Study: Colon Cancer

NCT ID: NCT04259398

Last Updated: 2023-11-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

797 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-02-18

Study Completion Date

2028-05-03

Brief Summary

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This study investigates the influence of type of anesthesia on survival and recurrence rate in patients receiving colon cancer surgery. The participants will be allocated to either the TIVA group and the inhalation group.

Detailed Description

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The effect of anesthesia on cancer recurrence and survival is controversial. According to some retrospective studies and preclinical studies, total intravenous anesthesia (TIVA) is suggested to be more favorable than inhalation anesthesia regarding cancer recurrence and survival after surgery. However, there is no randomized controlled study to determine this difference in colon cancer patients.

Conditions

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Cancer of Colon Anesthesia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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TIVA

propofol infusion targeting bispectral index 40-60

Group Type EXPERIMENTAL

Propofol

Intervention Type DRUG

propofol 1-2 mg/kg bolus injection for induction of anesthesia propofol continuous infusion for maintenance of anesthesia

inhalation (Sevoflurane)

sevoflurane targeting bispectral index 40-60

Group Type ACTIVE_COMPARATOR

Sevoflurane

Intervention Type DRUG

sevoflurane is administered for induction and maintenance of anesthesia

Interventions

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Propofol

propofol 1-2 mg/kg bolus injection for induction of anesthesia propofol continuous infusion for maintenance of anesthesia

Intervention Type DRUG

Sevoflurane

sevoflurane is administered for induction and maintenance of anesthesia

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* adults undergoing surgery to remove colon cancer

Exclusion Criteria

* pregnancy
* colon cancer with invasion to perineum
* palliative surgery
* history of diagnosis or surgery for other cancer
* emergent surgery
* ASA PS classification 4 and 5
* refusion to participate in the study
* allergy to anesthetics
Minimum Eligible Age

19 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Korean Society of Anesthesiologists

UNKNOWN

Sponsor Role collaborator

Seoul National University Bundang Hospital

OTHER

Sponsor Role collaborator

Chung-Ang University Hosptial, Chung-Ang University College of Medicine

OTHER

Sponsor Role collaborator

Seoul St. Mary's Hospital

OTHER

Sponsor Role collaborator

Seoul National University Boramae Hospital

OTHER

Sponsor Role collaborator

Seoul National University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Jin-Tae Kim

Professor (full)

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Seoul Metropolitan Government Seoul National University Boramae Medical Center

Seoul, , South Korea

Site Status

Seoul National University Hospital

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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Ane-Can colon (1912-133-109)

Identifier Type: -

Identifier Source: org_study_id