Anesthesia and Cancer Study: Renal Cell Carcinoma

NCT ID: NCT04503148

Last Updated: 2024-07-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

562 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-09-22

Study Completion Date

2025-12-22

Brief Summary

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This study investigates the influence of type of anesthesia on recurrence and survival of renal cell carcinoma in patients undergoing nephrectomy. The participants will be allocated to either the group receiving the total intravenous anesthesia (TIVA) using propofol or the group receiving the inhaled anesthetics, such as sevoflurane or desflurane.

Detailed Description

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The effect of anesthesia on cancer recurrence and survival is controversial. According to some retrospective studies and preclinical studies, TIVA is suggested to be more favorable than inhalation anesthesia regarding cancer recurrence and survival after surgery. However, to our knowledge, there is no study which investigates the influence of type of anesthesia on recurrence of renal cell carcinoma after nephrectomy.

Conditions

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Renal Cell Carcinoma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

A prospective randomized controlled study
Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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TIVA group

Patients receiving the total intravenous anesthesia using propofol

Group Type EXPERIMENTAL

Propofol

Intervention Type DRUG

Propofol 1-2 mg/kg bolus injection for induction of anesthesia propofol continuous infusion for maintenance of anesthesia

inhalation group

Patients receiving inhalation anesthesia using sevoflurane or desflurane

Group Type ACTIVE_COMPARATOR

Inhaled General Anesthetics

Intervention Type DRUG

Sevoflurane or desflurane for induction and maintenance of anesthesia

Interventions

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Propofol

Propofol 1-2 mg/kg bolus injection for induction of anesthesia propofol continuous infusion for maintenance of anesthesia

Intervention Type DRUG

Inhaled General Anesthetics

Sevoflurane or desflurane for induction and maintenance of anesthesia

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Adult patients scheduled for elective nephrectomy due to renal cell carcinoma

Exclusion Criteria

* Emergency surgery
* Pregnancy
* Allergies to anesthetics
* Palliative surgery
* Refusal to participate in the study
* History of diagnosis or surgery for other cancer
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Seoul National University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Jin-Tae Kim

professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Seoul National University Hospital

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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Ane-Can Nx

Identifier Type: -

Identifier Source: org_study_id

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