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Effect of Anaesthesia on ER Stress in Cancer Patients

NCT ID: NCT03561831

Last Updated: 2021-10-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

53 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-06-05

Study Completion Date

2019-05-29

Brief Summary

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Investigate the change in endoplasmic reticulum stress after cancer surgery according to different anaesthetics including propofol and sevoflurane.

Detailed Description

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We hypothesize propofol and sevoflurane based anesthesia would show different pattern of endoplasmic reticulum stress after cancer surgery in patients with cancer

Conditions

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Endoplasmic Reticulum Stress

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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propofol group

patients who anesthesized by propofol

Group Type ACTIVE_COMPARATOR

Propofol

Intervention Type DRUG

propofol based anesthesia

sevoflurane group

patients who anesthesized by sevoflurane

Group Type ACTIVE_COMPARATOR

Sevoflurane

Intervention Type DRUG

sevoflurane based anesthesia

Interventions

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Propofol

propofol based anesthesia

Intervention Type DRUG

Sevoflurane

sevoflurane based anesthesia

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

\- patients with cancer

Exclusion Criteria

* age under 19 years old
* allergy history to propofol or sevoflurane
* history of previous cancer
Minimum Eligible Age

20 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Konkuk University Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Seong-Hyop Kim

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Seong-Hyop Kim, Professor

Role: PRINCIPAL_INVESTIGATOR

Konkuk University Medical Center

Locations

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Konkuk University Medical Center

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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KUH1160108

Identifier Type: -

Identifier Source: org_study_id