Effects of Total Intravenous Anesthesia With Propofol-remifentanil Versus Inhalational Anesthesia With Sevoflurane on Quality of Recovery in Patients Undergoing Transsphenoidal Surgery for Pituitary Tumor
NCT ID: NCT02813044
Last Updated: 2020-09-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
82 participants
INTERVENTIONAL
2016-06-16
2018-06-15
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
OTHER
DOUBLE
Study Groups
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TIVA group
Anesthesia is maintained with propofol during surgery
total intravenous anesthesia (TIVA)
In the TIVA group,anesthesia is induced and maintained by effect-site target controlled infusion of propofol and remifentanil.
inhalation anesthesia group
Anesthesia is maintained with sevoflurane during surgery
inhalation anesthesia group
In the inhalation anesthesia group, anesthesia is induced by pentothal sodium 4-6mg/kg and remifentanil 1 μg/kg, and then maintained with end-tidal sevoflurane concentration of 0.8 to 1 MAC and continuous infusion of remifentanil at 0.1-0.3μg/kg/min.
Interventions
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total intravenous anesthesia (TIVA)
In the TIVA group,anesthesia is induced and maintained by effect-site target controlled infusion of propofol and remifentanil.
inhalation anesthesia group
In the inhalation anesthesia group, anesthesia is induced by pentothal sodium 4-6mg/kg and remifentanil 1 μg/kg, and then maintained with end-tidal sevoflurane concentration of 0.8 to 1 MAC and continuous infusion of remifentanil at 0.1-0.3μg/kg/min.
Eligibility Criteria
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Inclusion Criteria
* Scheduled to undergo transsphenoidal surgery for pituitary tumor
* ASA class I and II
Exclusion Criteria
* Third-degree atrioventricular block
* Second-degree atrioventricular block (P:QRS ratio of 3:1 or higher)
* Fever
* History of myocardial infarction, stroke or cardiac surgery within the previous 1 year
* Severe neurological disease
* Use of sedative, opioid or sleep-inducing drugs
* Allergic history of any study drug
* Pregnancy
19 Years
ALL
No
Sponsors
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Yonsei University
OTHER
Responsible Party
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Locations
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Associate Professor Department of Anesthesiology and Pain Medicine,
Seoul, , South Korea
Countries
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References
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Al-Shaikh B, George William M, Van Zundert AA. Using atmospheric pressure to inflate the cuff of the Portex Laryngeal Mask. Anaesthesia. 2005 Mar;60(3):296-7. doi: 10.1111/j.1365-2044.2005.04135.x. No abstract available.
Other Identifiers
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4-2016-0344
Identifier Type: -
Identifier Source: org_study_id
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