The Impact of Intraoperative Systemic Lidocaine Infusion on Chronic Postoperative Pain After Video-assisted Thoracic Surgery (VATS)

NCT ID: NCT02006966

Last Updated: 2019-04-01

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 168 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2014-01-31
• Study Completion Date: 2016-08-22

Brief Summary

Systemic lidocaine infusion may improve the patients' chronic post surgical pain after video-assisted thoracic surgery

Conditions

Lung Cancer(Primary, Metastatic); Benign Lung Mass Requiring Operation

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: SUPPORTIVE_CARE
• Blinding Strategy: DOUBLE

Study Groups

Group L

Intravenous lidocaine infusion group

Group Type: EXPERIMENTAL

Systemic intravenous lidocaine infusion

Intervention Type: DRUG

In group L, intravenous lidocaine infusion(0.1mg/kg) for 10minutes after induction of anesthesia. After 10 minutes, lidocaine infusion continued at rate of 3mg/kg/hr during operation, and discontinued before move the patients to PACU.

Group C

Intravenous normal saline infusion - control group

Group Type: ACTIVE_COMPARATOR

Normal saline infusion

Intervention Type: DRUG

In group C, the patients receive same volume of normal saline

Interventions

Systemic intravenous lidocaine infusion

In group L, intravenous lidocaine infusion(0.1mg/kg) for 10minutes after induction of anesthesia. After 10 minutes, lidocaine infusion continued at rate of 3mg/kg/hr during operation, and discontinued before move the patients to PACU.

Intervention Type: DRUG

Normal saline infusion

In group C, the patients receive same volume of normal saline

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Age between 20 and 65 years
• ASA class 1 and 2
• Patients who are scheduled for video-assisted thoracic surgery

Exclusion Criteria

• Allergy to local anesthetics or contraindication to use of lidocaine
• Pregnancy
• Severe cardiovascular disease
• Renal failure
• Liver failure
• Neurologic and psychologic disease
• Chronic treatment with analgesics or chronic pain patients
• Previous history of thoracic surgery (open or video-assisted)
• Patients' refusal

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Yonsei University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine

Seoul, , South Korea

Countries

South Korea

Other Identifiers

4-2013-0693

Identifier Type: -

Identifier Source: org_study_id