Human Oral Detection of Glucose Olygomers

NCT ID: NCT02589353

Last Updated: 2023-02-21

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE4
• Total Enrollment: 157 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2017-04-21
• Study Completion Date: 2023-02-16

Brief Summary

Although salivary contents play a major role in the early stage of food digestion process, their role in taste perception of glucose polymers is essentially unknown. It is hypothesized that the differences in salivary contents, more specifically salivary amylase concentration and activity, influence taste perception of glucose polymers and ultimately eating behavior, which is related to risks in various diseases. The current project will investigate the variation in salivary contents across individuals and its role in taste perception of glucose polymers.

Conditions

Healthy Volunteers

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Acarbose

Acarbose solution will be swabbed on the tip of the tongue to inhibit salivary alpha amylase activity; each swab will contain \~484 microgram acarbose; total maximum exposure of each subject to acarbose will be \~14-30 mg each session (1-20 sessions)

Group Type: EXPERIMENTAL

Acarbose

Intervention Type: DRUG

Acarbose solution will be swabbed on the tip of the tongue to inhibit salivary alpha amylase activity; each swab will contain \~484 microgram acarbose; total maximum exposure of each subject to acarbose will be \~14-30 mg each session (1-20 sessions)

Interventions

Acarbose

Acarbose solution will be swabbed on the tip of the tongue to inhibit salivary alpha amylase activity; each swab will contain \~484 microgram acarbose; total maximum exposure of each subject to acarbose will be \~14-30 mg each session (1-20 sessions)

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• self-reported healthy adults between the ages of 18-60 who are fluent in English.

Exclusion Criteria

• adults 61 years old and above
• smokers
• pregnant women
• taking any prescription pain/ insulin medication
• has a history of taste or smell loss or other oral disorders (e.g., burning mouth syndrome)
• has current oral lesions, canker sores, or piercings
• has a history of food allergy

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Oregon State University

OTHER

Sponsor Role: lead

Responsible Party

Juyun Lim

Associate Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Juyun Lim

Role: PRINCIPAL_INVESTIGATOR

Oregon State University

Locations

Department of Food Science and Technology

Corvallis, Oregon, United States

Countries

United States

Other Identifiers

IRB # 5373

Identifier Type: -

Identifier Source: org_study_id