Gustin Gene Polymorphism and 6-n-propylthiouracil (PROP) Taste

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

170 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-10-31

Study Completion Date

2016-06-30

Brief Summary

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The investigators evaluate the possible association of PROP taste with gustin gene polymorphism rs2274333 (A/G), salivary zinc ion concentration and BMI. In addition, it has also been evaluated PROP taste sensitivity by recording monophasic potentials from the tongue.

Detailed Description

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The investigators evaluate the possible association of PROP taste with gustin gene polymorphism rs2274333 (A/G), salivary zinc ion concentration and BMI.

Furthermore, we apply direct measures of the gustatory system activation following stimulation with PROP, obtained by electrophysiological recordings from the tongue of subjects classified for taster status, genotyped for the specific receptor gene (TAS2R38), and in which papilla density was determined.

Conditions

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Dysgeusia

Keywords

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PROP taste sensitivity Gustin (CAVI) polymorphism Salivary zinc BMI Electrophysiological recording from the tongue

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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PROP taste sensitivity

PROP Sensitive and non sensitive individuals are defined as "Tasters" and "Non-tasters", respectively. Taster are further divided in "Super-taster" who perceived PROP as extremely bitter and "Medium tasters" who perceived PROP as moderately bitter.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* no variation of body weight \> 5 kg over the last 3 mo BMI within 20-25 Age between 20-30

Exclusion Criteria

* gustatory impairment following a prescribed diet or using medications that might interfere with taste perception food allergies smokers

Minimum Eligible Age

20 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

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Iole Tomassini Barbarossa

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Iole Tomassini Barbarossa, PhD

Role: PRINCIPAL_INVESTIGATOR

Dip. Scienze Biomediche Sezione di Fisiologia Università di Cagliari

Locations

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Sezione di Farmacologia Clinica del Dipartimento di Neuroscienze, San Giovanni di Dio Azienda Ospedaliero Universitaria di Cagliari

Cagliari, Ca, Italy

Site Status

Countries

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Italy

References

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Padiglia A, Zonza A, Atzori E, Chillotti C, Calo C, Tepper BJ, Barbarossa IT. Sensitivity to 6-n-propylthiouracil is associated with gustin (carbonic anhydrase VI) gene polymorphism, salivary zinc, and body mass index in humans. Am J Clin Nutr. 2010 Sep;92(3):539-45. doi: 10.3945/ajcn.2010.29418. Epub 2010 Jul 14.

Reference Type DERIVED

PMID: 20631203 (View on PubMed)

Other Identifiers

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UNICADBSITB-1

Identifier Type: -

Identifier Source: org_study_id