Effect of Natural Antibacterial Mouthwash on Taste, Salivary pH and Bacteria in High Caries Risk pt

NCT ID: NCT03623048

Last Updated: 2018-09-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-03-31

Study Completion Date

2019-04-30

Brief Summary

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Evaluate the effect of propolis extract mouthwash and pomegranate extract mouthwash on taste alteration, salivary pH and antibacterial activity against streptococcus mutans in high caries risk patients.

Detailed Description

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This study will be carried out to evaluate and compare the effect of propolis extract mouthwash and pomegranate (botanical name: Punica granatum) extract mouthwash on taste alteration, salivary pH and antibacterial activity against streptococcus mutans in high caries risk patients.

Thats by taking unstimulated saliva samples at the morning before using the mouthwash, then taking another one after using the mouthwash and finally after 7 days, to make a bacterial culture and measure the salivary pH by a digital pH meter and evaluate taste changes by a questionnaire.

Conditions

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Decay, Dental

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Propolis extract

intervention

Group Type EXPERIMENTAL

Propolis extract

Intervention Type OTHER

antibacterial mouthwash

Pomegranate extract

intervention

Group Type EXPERIMENTAL

pomegranate extract

Intervention Type OTHER

antibacterial mouthwash

Chlorhexidine

comparator

Group Type ACTIVE_COMPARATOR

chlorhexidine

Intervention Type OTHER

antibacterial and anti-inflammatory mouthwash

Saline

comparator

Group Type PLACEBO_COMPARATOR

saline

Intervention Type OTHER

anti-inflammatory cleansing mouthwash

Interventions

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chlorhexidine

antibacterial and anti-inflammatory mouthwash

Intervention Type OTHER

saline

anti-inflammatory cleansing mouthwash

Intervention Type OTHER

Propolis extract

antibacterial mouthwash

Intervention Type OTHER

pomegranate extract

antibacterial mouthwash

Intervention Type OTHER

Other Intervention Names

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hexitol NaCl solution

Eligibility Criteria

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Inclusion Criteria

* High caries risk patients defined according to American Dental Association (ADA)
* Systematically healthy
* Not taking any medication interfering with saliva secretion
* Subjects who signed informed consent
* Age range from 17-50 years

Exclusion Criteria

* Subjects suffering from any medical or systematic disease
* Smokers
* Pregnant females
* Allergy to any of the mouthwash ingredients
* Patients older than 50 years
Minimum Eligible Age

17 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Cairo University

OTHER

Sponsor Role lead

Responsible Party

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Randa Abdelrahman

Assistant lecturer

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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CEBD-CU-2018-08-04

Identifier Type: -

Identifier Source: org_study_id

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