Efficacy of Natural Enzymes Mouthwash: a Randomised Controlled Trial
NCT ID: NCT05640362
Last Updated: 2022-12-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
48 participants
INTERVENTIONAL
2016-11-10
2017-03-24
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
QUADRUPLE
Study Groups
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Benzydamine mouthwash
Benzydamine mouthwash
Subjects were instructed to rinse with the mouthwash 4 times per day at a specific period, for 2 weeks.
Natural enzymes mouthwash
Natural enzymes mouthwash
Natural enzymes mouthwash contains numerous natural protein-enzymes, including lactoferrin, lysozyme, lactoperoxidase, glucose oxidase. These active ingredients were proposed to render this mouthwash to act as salivary substitutes by reinforcing the functions of available saliva, hence reinforcing the immune system in the oral cavity. It was expected to relieve the symptoms in xerostomia patients, and even more if the patients have salivary flow reduction by improving the functions of the limited amount of saliva. The potential mechanisms of action of the mouthwash to treat xerostomia may be related to: (1) lubrication effects to wet the oral mucosal surfaces; (2) antimicrobial properties that will reduce risks of mucosal irritation by infections; (3) absence of alcohol in the mouthwash Subjects were instructed to rinse with the mouthwash 4 times per day at a specific period, for 2 weeks.
Interventions
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Natural enzymes mouthwash
Natural enzymes mouthwash contains numerous natural protein-enzymes, including lactoferrin, lysozyme, lactoperoxidase, glucose oxidase. These active ingredients were proposed to render this mouthwash to act as salivary substitutes by reinforcing the functions of available saliva, hence reinforcing the immune system in the oral cavity. It was expected to relieve the symptoms in xerostomia patients, and even more if the patients have salivary flow reduction by improving the functions of the limited amount of saliva. The potential mechanisms of action of the mouthwash to treat xerostomia may be related to: (1) lubrication effects to wet the oral mucosal surfaces; (2) antimicrobial properties that will reduce risks of mucosal irritation by infections; (3) absence of alcohol in the mouthwash Subjects were instructed to rinse with the mouthwash 4 times per day at a specific period, for 2 weeks.
Benzydamine mouthwash
Subjects were instructed to rinse with the mouthwash 4 times per day at a specific period, for 2 weeks.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* complained of dry mouth (xerostomia), and
* taking nutrition orally
Exclusion Criteria
* unable to provide saliva samples,
* unable to chew paraffin wax for stimulated saliva,
* patients with oral motor function deficits, and
* those with severe cognitive deterioration.
18 Years
ALL
Yes
Sponsors
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National University of Malaysia
OTHER
Responsible Party
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Principal Investigators
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Rifqah Nordin, MClinDent
Role: PRINCIPAL_INVESTIGATOR
National University of Malaysia
Locations
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Faculty of Dentistry, Universiti Kebangsaan Malaysia
Kuala Lumpur, , Malaysia
Countries
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References
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Chiam TL, Choo J, Ashar A, Hussaini HM, Rajandram RK, Nordin R. Efficacy of natural enzymes mouthwash: a randomised controlled trial. Clin Oral Investig. 2024 Apr 19;28(5):259. doi: 10.1007/s00784-024-05658-7.
Other Identifiers
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UKM PPI/111/8/JEP-2016-582
Identifier Type: -
Identifier Source: org_study_id
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