Effect of Photobiomodulation on ph and Salivary Flow

NCT ID: NCT05413993

Last Updated: 2022-06-10

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-03-10
• Study Completion Date: 2022-05-20

Brief Summary

Changes in salivary parameters, such as decreased flow, changes in pH and composition, can lead to changes in oral health. Saliva is responsible for the homeostasis of the oral cavity and is therefore directly related to the occurrence of caries, periodontitis, fungal and bacterial infections. These situations compromise the quality of life of the population and for this reason prevention and treatment strategies need to be studied and developed. Photobiomodulation is an alternative that has been increasingly practiced by health professionals. It consists of the application of light to a biological system that is capable of inducing a photochemical process, mainly in the mitochondria, thus stimulating the production of energy in the form of adenosine triphosphate (ATP), which can increase cellular metabolism and produce effects. as analgesia and tissue regeneration. In dentistry, studies using photobiomodulation have shown promise in improving some salivary parameters. This study aimed to compare the action of infrared light on salivary flow and pH, using two application techniques: extraoral (G1) and intra and extraoral (G2), with the application interval between the two techniques being 7 days

Detailed Description

This is a quasi-experimental clinical study evaluating the flow and salivary pH of healthy adults. The study was carried out with 20 adult patients at the Nove de Julho University. This study aimed to compare the action of infrared light on salivary flow and pH, using two application techniques: extraoral (G1) and intra and extraoral (G2), with the application interval between the two techniques being 7 days. The sample consisted of 20 healthy adults, who participated in both groups, thus being the actual control in the evaluations. Stimulated saliva was collected in both groups before and immediately after light application. In G1, a cluster with 3 spots was used, at a wavelength of 808 nanometers, power of 120 mW, with 24J of energy on the extraoral surface, for 67 seconds, in the region of the parotid gland, region of the submandibular and sublingual glands bilaterally, totaling 4 application regions, with total deposited energy of 96 joules. In G2, the laser was applied for 60 seconds, in 2 intraoral and 2 extraoral points in the region of the parotid glands bilaterally, as well as 1 intraoral and 1 extraoral point in the regions of the submandibular and sublingual glands (totaling 16 points), with a central wavelength of 808 nm; continuous operating mode; power of 100mW; with an aperture diameter of 0.354 cm (with spacer); radiant energy of 6J per point, totaling 96 joules of energy.

Conditions

Xerostomia

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

intra and extraoral application

The laser was applied for 60 seconds, in 2 intraoral points and 2 extraoral points.

Group Type: ACTIVE_COMPARATOR

photobiomodulation

Intervention Type: RADIATION

Laser application intraorals and extraoral points in the region of the salivary glands bilaterally

extraoral application

The laser was applied only extraoral points

Group Type: EXPERIMENTAL

photobiomodulation

Intervention Type: RADIATION

Laser application intraorals and extraoral points in the region of the salivary glands bilaterally

Interventions

photobiomodulation

Laser application intraorals and extraoral points in the region of the salivary glands bilaterally

Intervention Type: RADIATION

Eligibility Criteria

Inclusion Criteria

• Healthy adults over 18 years of age
• healthy dentition.

Exclusion Criteria

• dental caries
• gingivitis or other alterations in the oral cavity
• who use medication that has the side effect of decreasing the salivary flow,
• who have used an antibiotic or anti-inflammatory within the last 30 days,
• diabetes.

• Minimum Eligible Age: 10 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Nove de Julho

OTHER

Sponsor Role: lead

Responsible Party

Lara Jansiski Motta

PhD

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Nove de Julho Univ

São Paulo, São Paulo, Brazil

Countries

Brazil

Other Identifiers

PBMSF

Identifier Type: -

Identifier Source: org_study_id