Liquorice and Salivary Cortisol

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-10-16

Study Completion Date

2020-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Salivary cortisol is used as a diagnostic analysis in the investigation of suspected Cushings' syndrome. This study evaluates if liqourice intake increases salivary cortisol in healthy individuals. Late night salivary cortisol and cortisone is analysed before, during and after 7 days of liqourice intake in three different doses.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

An Investigation Into the Effect of Liquorice Ingestion on the Salivary Cortisol to Cortisone Molar Ratio

NCT02939144

Apparent Mineralocorticoid Excess

COMPLETED NA

Salivary Cortisol Measurement in Corticotrope Deficiency Substitution With Hydrocortisone.

NCT05457296

Adrenal Insufficiency

COMPLETED PHASE4

Discriminant Capacity and Thresholds of Salivary Cortisol in Chemiluminescence in the Diagnosis of Hypercorticisms

NCT03974789

Cushing Disease

ACTIVE_NOT_RECRUITING

Assessment of Diurnal Salivary Cortisol Production in COVID-19

NCT04988269

COVID-19 Adrenal Insufficiency Adrenal Hyperfunction

COMPLETED

Establishment and Clinical Application of Reference Intervals of Salivary Cortisol

NCT07168122

Healthy Adult Cushing Syndrome Adrenal Insufficiency

RECRUITING

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Cushing Syndrome Hypercortisolism

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Each group of 10 individuals uses liqourice for 7 days and late night salivary cortisol and cortisone is analysed before (baseline), during and after (washout) intake.

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

glycyrrhizic acid 1.5 mg/kg body weight

Liqourice corresponding to 1.5 mg glycyrrhizic acid per kg body weight is taken in the evening during 7 days.

Group Type ACTIVE_COMPARATOR

Liqourice

Intervention Type DIETARY_SUPPLEMENT

Liqourice corresponding to 1.5, 3.0 or 6.0 mg glycyrrhizic acid per kg body weight is taken in the evening during 7 days.

glycyrrhizic acid 3.0 mg/kg body weight

Liqourice corresponding to 3.0 mg glycyrrhizic acid per kg body weight is taken in the evening during 7 days.

Group Type ACTIVE_COMPARATOR

Liqourice

Intervention Type DIETARY_SUPPLEMENT

Liqourice corresponding to 1.5, 3.0 or 6.0 mg glycyrrhizic acid per kg body weight is taken in the evening during 7 days.

glycyrrhizic acid 6.0 mg/kg body weight

Liqourice corresponding to 6.0 mg glycyrrhizic acid per kg body weight is taken in the evening during 7 days.

Group Type ACTIVE_COMPARATOR

Liqourice

Intervention Type DIETARY_SUPPLEMENT

Liqourice corresponding to 1.5, 3.0 or 6.0 mg glycyrrhizic acid per kg body weight is taken in the evening during 7 days.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Liqourice

Liqourice corresponding to 1.5, 3.0 or 6.0 mg glycyrrhizic acid per kg body weight is taken in the evening during 7 days.

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

glycyrrhizic acid

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Men and women 18-65 years.

Exclusion Criteria

* Known pituitary or adrenal disease
* Medication with glucocorticoids (incl. inhalation, nasal, dermal)
* Known hypertension or blood pressure \>140/90 at screening
* tobacco use
* Subjective problems in oral mucosa or saliva
* Abnormal diurnal rhythm (awake 03:00 - 05:30)
* Difficulties taking liqourice for 3 weeks or refraining from liqourice during 4 weeks

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes