Real-time Monitoring of Cortisol - Comparison of Cortisol Levels in Four Biological Fluids
NCT ID: NCT06008184
Last Updated: 2023-09-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
12 participants
OBSERVATIONAL
2021-09-01
2024-08-31
Brief Summary
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Therefore, a non-invasive and ambulatory method would be useful to measure cortisol levels in real-time.
The main aim of the study is to compare cortisol levels across biological fluids (sweat, saliva, interstitial fluid, and blood) in order to validate in the long term a continuous and non-invasive cortisol measurement device (currently under development).
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Detailed Description
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Conditions
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Study Design
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OTHER
PROSPECTIVE
Study Groups
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Healthy controls
24 hours sampling of 4 biological fluids (blood, ISF, sweat and saliva)
24 hours sampling of 4 biological fluids:
* blood: sampling every 20 minutes (through a venous catheter)
* ISF: automated sampling every 20 minutes (microdialysis technique connected to U-Rhythm device)
* Sweat : collection of 1 to 3 samples at 4 differents timepoints
* Saliva : sampling every hour (except during the night)
24 hours sampling of ISF or sweat (after validating the correlation with blood)
24 hours sampling in an ambulatory setting
Interventions
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24 hours sampling of 4 biological fluids (blood, ISF, sweat and saliva)
24 hours sampling of 4 biological fluids:
* blood: sampling every 20 minutes (through a venous catheter)
* ISF: automated sampling every 20 minutes (microdialysis technique connected to U-Rhythm device)
* Sweat : collection of 1 to 3 samples at 4 differents timepoints
* Saliva : sampling every hour (except during the night)
24 hours sampling of ISF or sweat (after validating the correlation with blood)
24 hours sampling in an ambulatory setting
Eligibility Criteria
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Inclusion Criteria
* normal BMI 18 to 25 kg/m2
* weight stability
Exclusion Criteria
* any medical treatment
* any medical issues
* pilocarpine allergy, or latex allergy
* glaucoma or acute irritis
18 Years
30 Years
ALL
Yes
Sponsors
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Centre Hospitalier Universitaire Vaudois
OTHER
Responsible Party
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Nelly Pitteloud
Professor
Principal Investigators
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Nelly Pitteloud, MD
Role: PRINCIPAL_INVESTIGATOR
Centre Hospitalier Universitaire Vaudois
Locations
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Centre Hospitalier Universitaire Vaudois (CHUV)
Lausanne, Canton of Vaud, Switzerland
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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CER-VD : 2021-01674
Identifier Type: -
Identifier Source: org_study_id
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