Evaluation of Emotion-related Salivary Molecular Biomarkers

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

240 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-11-14

Study Completion Date

2027-06-14

Brief Summary

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Recent studies show that emotional states can be discriminated by physiological responses. This physiological regulation results from the action of enzymes and hormones that represent the activity of the autonomic nervous system. The measurement of specific biomarkers, using non-invasive biological tests in saliva, would therefore provide physiological data on an individual's emotional state in response to stimuli, particularly olfactory stimuli.

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Detailed Description

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Recent studies show that emotional states (positive and negative) can be discriminated by physiological responses. This physiological regulation stems from the action of enzymes and hormones that represent the activity of the autonomic nervous system. The measurement of specific biomarkers (enzymes, hormones), using non-invasive biological tests in saliva, would therefore provide physiological data on an individual's emotional state (Giacomello et al. 2020) in response to stimuli, particularly olfactory stimuli.

The aim of the proposed research is to identify and measure a signature of molecular biomarkers in saliva, linked to emotions following one or more olfactory stimuli (e.g. cortisol and alpha-amylase concentration increase after stimulation).

Conditions

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Emotion

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Bras S Fragrance then placebo

Subjects will be subjected successively to fragrance and placebo stimulation.

Identication and measurement of a molecular biomarkers signature

Intervention Type OTHER

Levels of the biomarkers of interest (DHEA, pg/mL; Oxytocin, pg/mL; Cortisol, pg/mL; Alpha Amylase, U/mL) will be measured in the saliva of participating subjects by enzymatic assay methods or ELISA-type methods performed using commercial kits.

Bras P Placebo then fragrance

Subjects will be subjected successively to placebo and fragrance stimulation.

Identication and measurement of a molecular biomarkers signature

Intervention Type OTHER

Levels of the biomarkers of interest (DHEA, pg/mL; Oxytocin, pg/mL; Cortisol, pg/mL; Alpha Amylase, U/mL) will be measured in the saliva of participating subjects by enzymatic assay methods or ELISA-type methods performed using commercial kits.

Interventions

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Identication and measurement of a molecular biomarkers signature

Levels of the biomarkers of interest (DHEA, pg/mL; Oxytocin, pg/mL; Cortisol, pg/mL; Alpha Amylase, U/mL) will be measured in the saliva of participating subjects by enzymatic assay methods or ELISA-type methods performed using commercial kits.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Subject willing to follow study procedures
* Subject able to understand the purpose, nature and methodology of the study
* Subject has signed informed consent form
* Subjects between 18 and 60 years of age.

* Pregnant or breastfeeding women
* Subjects presenting anosmia during the last 15 days
* Subjects presenting symptoms and signs of active oral inflammation, advanced periodontitis or severe gingivitis.

Exclusion Criteria

* Subjects deprived of liberty, protected adults, vulnerable persons or minors
* Subjects with a proven or suspected chronic infectious disease that could entail a risk of contamination during sample handling (laboratories not equipped to handle this type of sample)
* Rejection to sign the consent form.

Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes