Identification of Pathophysiological Pathways and Therapeutic Targets in Primary Stomatodynia by Salivary Metabolomics

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

53 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-03-10

Study Completion Date

2021-05-12

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Burning mouth syndrome (BMS) is defined by a chronic oral pain affecting especially postmenopausal women. Its physiopathology is still unknown and several hypotheses have been put forward to explain this syndrome, such as neurological, hormonal or inflammatory process. The recent development of salivary metabolomic profiling in oral diseases has led to the identification of potential pathways in such disorders. The aim of this study is to analyze the salivary metabolomic in BMS patients compared to healthy controls.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Effect of Treatments on Pain and Quality of Life in Individual With Burning Mouth Syndrome

NCT06040190

Burning Mouth Syndrome

RECRUITING PHASE4

Effect to the Photobiomodulation in the Burning Mouth Syndrome

NCT05871580

Burning Mouth Syndrome Quality of Life Anxiety Depression +1 more

COMPLETED NA

Burning Mouth Syndrome: Symptoms and Management

NCT07016555

Burning Mouth Syndrome

RECRUITING EARLY_PHASE1

Neurogenic Mechanisms in Burning Mouth Syndrome

NCT00875537

Burning Mouth Syndrome

COMPLETED NA

Burning Mouth Disorder (BMD) - A Neuropathic Pain Disorder

NCT00504387

Burning Mouth Syndrome Taste Disorder Orofacial Pain

UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Burning mouth syndrome (BMS) is defined by a chronic oral pain affecting especially postmenopausal women. Its physiopathology is still unknown and several hypotheses have been put forward to explain this syndrome, such as neurological, hormonal or inflammatory process. The recent development of salivary metabolomic profiling in oral diseases has led to the identification of potential pathways in such disorders. The aim of this study is to analyze the salivary metabolomic in BMS patients compared to healthy controls.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Primary Burning Mouth Syndrome

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Case group

women with primary stomatodynia

Salivic sample

Intervention Type OTHER

Collection of total saliva not stimulated

Control group

women without oral disease

Salivic sample

Intervention Type OTHER

Collection of total saliva not stimulated

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Salivic sample

Collection of total saliva not stimulated

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* For cases : primary Burning Mouth Syndrome, based on the IHS diagnosis criteria
* For cases : being able to realise the salivary collection
* For controls : no primary BMS
* For controls : being able to realise the salivary collection

Exclusion Criteria

* Treatment by antibiotics in the previous month
* New treatment in the previous two weeks
* Active smoking
* Active infectious or inflammatory oral disease
* Systemic disease that could have an impact on the salivary metabolome or on the neurological system
* Being under legal guardianship
* Opposition to the processing of personal data

Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes