Acute Effects of Fats on Satiety and Energy Needs

NCT ID: NCT02496936

Last Updated: 2022-08-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

23 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-12-31

Study Completion Date

2019-10-30

Brief Summary

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The purpose of this study is to assess the acute effect of dietary fat on satiety and energy metabolism.

Detailed Description

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The influences of specific dietary fat sources on satiety, appetite and energy utilization remains unclear; evidence is lacking on whether responses vary according to acute intake. The researchers will use a controlled setting to determine whether the source of dietary fat is related to perceived satiety, satiety hormone responses, and energy expenditure by conducting experiments to evaluate short term (acute) effects.

Conditions

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Obesity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

OTHER

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Saturated Fat (SFA)

30 grams saturated fat in the form of heavy whipping cream will be provided to subject in a smoothie drink

Group Type EXPERIMENTAL

SFA

Intervention Type OTHER

High saturated fatty acid/SFA oil source

Monounsaturated Fat (MUFA)

30 grams monounsaturated fat in the form of high oleic canola oil will be provided to subject in a smoothie drink

Group Type EXPERIMENTAL

MUFA

Intervention Type OTHER

High monounsaturated fatty acid/MUFA oil source

Polyunsaturated Fat Linoleic (PUFA-LA)

30 grams polyunsaturated fat in the form of high linoleic sunflower oil will be provided to subject in a smoothie drink

Group Type EXPERIMENTAL

PUFA-LA

Intervention Type OTHER

High polyunsaturated fatty acid (linoleic)/PUFA-LA oil source

Polyunsaturated Fat Alpha-Linolenic (ALA)

30 grams polyunsaturated fat in the form of flaxseed oil will be provided to subject in a smoothie drink

Group Type EXPERIMENTAL

ALA

Intervention Type OTHER

High polyunsaturated fatty acid (alpha-linolenic)/ALA oil source

Polyunsaturated Fat Long Chain Omega-3 (LCn3)

30 grams polyunsaturated fat in the form of fish oil (Coromega Omega3 Squeeze) will be provided to subject in a smoothie drink

Group Type EXPERIMENTAL

LCn3

Intervention Type OTHER

High polyunsaturated fatty acid (omega-3)/LCn3 oil source

Interventions

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SFA

High saturated fatty acid/SFA oil source

Intervention Type OTHER

MUFA

High monounsaturated fatty acid/MUFA oil source

Intervention Type OTHER

PUFA-LA

High polyunsaturated fatty acid (linoleic)/PUFA-LA oil source

Intervention Type OTHER

ALA

High polyunsaturated fatty acid (alpha-linolenic)/ALA oil source

Intervention Type OTHER

LCn3

High polyunsaturated fatty acid (omega-3)/LCn3 oil source

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* body mass index between 18.0-34.9 kg/m2
* free of major diagnosed, untreated medical conditions
* controlled hypertension
* non-smoking or use of other tobacco products, including e-cigarettes
* not taking steroid-based medications
* not planning to or currently attempting to gain or lose weight
* willing to comply with study demands
* use of oral contraceptives
* low intake of long chain omega 3 fatty acids

Exclusion Criteria

* diagnosed eating disorders
* diabetes (blood sugar ≥ 126 mg/dl)
* hypertension (systolic ≥ 160 mmHg or diastolic \> 100 mmHg)
* diagnosed cardiovascular, pulmonary, skeletal and metabolic disease
* currently pregnant or planning to become pregnant, or lactating
* taking medications known to affect appetite, blood lipids, body composition, body weight, or food intake (appetite control drugs, steroids, antidepressants)
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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USDA Grand Forks Human Nutrition Research Center

FED

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Matthew Picklo, PhD

Role: PRINCIPAL_INVESTIGATOR

USDA Grand Forks Human Nutrition Research Center

Locations

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USDA Grand Forks Human Nutrition Research Center

Grand Forks, North Dakota, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Informed Consent Form

View Document

Related Links

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https://www.ars.usda.gov/plains-area/gfnd/gfhnrc/docs/nutrition-studies/nutrition-studies/

Grand Forks Human Nutrition Research Center Current Nutrition Studies

Other Identifiers

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GFHNRC508

Identifier Type: -

Identifier Source: org_study_id

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