Chronic Effects of Fats on Satiety & Energy Needs

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

1 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-10-03

Study Completion Date

2018-05-24

Brief Summary

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The purpose of this study is to evaluate the effect of dietary fat on satiety (the experience of fullness between one meal and the next) and energy metabolism over an extended period of time (chronic effects). How dietary fat sources affect satiety, appetite and energy use is unclear. The investigators will use a controlled setting for the studies. They want to know if the source of dietary fat alters satiety, satiety hormones, and energy expenditure responses after consuming different diets.

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Detailed Description

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This work will address the interaction of obesity and dietary fatty acids in regulating satiety and energy metabolism. The primary objective is to determine the effects of chronic intake of dietary fatty acids of varied saturation and chain length on satiety, thermogenesis and energy utilization in healthy individuals. The investigators hypothesize that unsaturated fatty acids will 1) increase satiety and 2) increase energy metabolism and that 3) the fatty acid binding protein polymorphisms are associated with reduced energy expenditure in response to dietary fat intake.

Conditions

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Overweight Obesity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

OTHER

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Saturated Fat/SFA

30 grams saturated fat (SFA) in the form of heavy whipping cream will be provided to subject in a mixed meal shake

Group Type OTHER

SFA

Intervention Type OTHER

High saturated fatty acid/SFA oil source

Monounsaturated Fat/MUFA

30 grams monounsaturated fat (MUFA) in the form of olive oil will be provided to subject in a mixed meal shake

Group Type OTHER

MUFA

Intervention Type OTHER

High monounsaturated fatty acid/MUFA oil source

Polyunsaturated Fat Linoleic/PUFA

30 grams high linoleic polyunsaturated fat (PUFA) in the form of high linoleic sunflower oil will be provided to subject in a mixed meal shake

Group Type OTHER

PUFA

Intervention Type OTHER

High polyunsaturated fatty acid (linoleic)/PUFA oil source

Polyunsaturated Fat Omega-3/LCn3

30 grams high omega-3 polyunsaturated fat (LCn3) in the form of fish oil will be provided to subject in a mixed meal shake

Group Type OTHER

LCn3

Intervention Type OTHER

High polyunsaturated fatty acid (omega-3)/LCn3 oil source

Interventions

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SFA

High saturated fatty acid/SFA oil source

Intervention Type OTHER

MUFA

High monounsaturated fatty acid/MUFA oil source

Intervention Type OTHER

PUFA

High polyunsaturated fatty acid (linoleic)/PUFA oil source

Intervention Type OTHER

LCn3

High polyunsaturated fatty acid (omega-3)/LCn3 oil source

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* body mass index between 25.0-34.9 kg/m2
* free of major diagnosed, untreated medical conditions
* non-smoking or use of other tobacco products, including e-cigarettes
* not taking steroid-based medications
* not planning to or currently attempting to gain or lose weight
* willing to comply with study demands
* low intake of long chain omega-3 fatty acids (\<0.10 g/d) or willing to reduce intake for 6 weeks prior to starting the study

Exclusion Criteria

* diagnosed eating disorders
* diabetes (blood sugar ≥ 126 mg/dl)
* hypertension (systolic \> 160 mmHg or diastolic \> 100 mmHg)
* diagnosed cardiovascular, pulmonary, skeletal and metabolic diseases
* currently pregnant or planning to become pregnant, or lactating
* taking medications known to affect appetite, blood lipids, body composition, body weight, or food intake (appetite control drugs, steroids, antidepressants)

Minimum Eligible Age

20 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes