Fat Perception in Humans (09-0873)

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-05-31

Study Completion Date

2014-06-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

There are many substances naturally present in the mouth that may help us taste fat in food. Two of these substances (lipases and CD36) will be examined in this study.

The presence of fat in food increases food tastiness, therefore people often over-eat high-fat foods and gain weight. The purpose of this study is to determine if blocking lipases and some genetic variations in the CD36 gene will make fatty food less tasty so that people eat less. Our hypothesis is that Orlistat and a particular gene will increase one's ability to detect fat.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

CD36 and Human Fat Taste Perception

NCT02699567

Obesity

COMPLETED

Saliva Modification Related to Fat Perception in Human

NCT01532778

Fat Sensitivity

COMPLETED

Heritability and Genetics of Fat Taste

NCT02357316

Healthy

COMPLETED

Food Composition and Palatability

NCT02357329

Fat Taste

COMPLETED

Acute Effects of Fats on Satiety and Energy Needs

NCT02496936

Obesity

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

1. Determine the effect of lipolysis inhibition in oral cavity on orosensory detection of fat in humans.

Hypothesis: Orally applied Orlistat will increase detection thresholds of TAGs but not FFA in humans.

To test this hypothesis we will measure triolein (a TAG) and oleic acid (a FFA) taste detection thresholds with a three-alternative forced-choice (3-AFC) ascending concentration method under two conditions (Orlistat day vs. Control day). To control for olfactory input, subjects will be assessed wearing noseclips.
2. Determine the effect of CD36 variants on fat taste perception in humans. Hypothesis: SNPs that associate with reduced CD36 expression will be associated with higher FFA and TAG detection thresholds

To test this hypothesis we will measure triolein and oleic acid taste detection thresholds in subjects who carry of the common CD36 e-SNP rs1761667 (i.e. a SNP that significantly reduces CD36 level and has a minor allele frequency of 38-48%). We expect subjects who are at least heterozygous for the expression reducing allele to have higher triolein and oleic acid taste detection thresholds compared to non-carrier subjects.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Obesity

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

rs1761667- AA genotype

subjects carrying the CD36 genotype rs1761667, i.e. a Single Nucleotide Polymorphism that significantly reduces CD36 level and has a minor allele frequency of 38-48%.

No interventions assigned to this group

rs1761667-GG genotype

subjects who are homozygous of CD36 genotype rs1761667-G allele.

No interventions assigned to this group

rs1761667-AG genotype

Heterozygous of CD36 gene rs1761667-A genotype.

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Body Mass Index greater than 30 kg/m²

Exclusion Criteria

* smokers or who quit smoking less than six months ago
* pregnancy
* breastfeeding
* diabetes
* taking medications that might affect taste perception
* previous malabsorptive or restrictive intestinal surgery

Minimum Eligible Age

21 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes