Taste Perception and Chronic Disease Risk

NCT ID: NCT01023906

Last Updated: 2014-05-23

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 90 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2008-07-31
• Study Completion Date: 2010-03-31

Brief Summary

The purpose of the Taste Perception Study is to assess variations in the ability to taste and perceive sensations from various stimuli in younger (18-49 years) and older (50-85 years) volunteers. The study's goal is to determine how these sensations influence what one likes to eat, and what one chooses to eat, and whether there is an association with dietary intake, body composition and chronic disease. Another objective of the study is to determine the association between variations in oral sensations and genes mediating sensory perception and dietary behaviours.

Detailed Description

The objective of the Taste Perception Study is to assess variations in oral sensations in younger (18-49 years; n=35) relative to older (50-85 years; n=35) subjects, and determine the association between variations in oral sensations and measures of chronic disease risk factors, body composition, habitual dietary intake and selected genes mediating sensory perception and dietary behaviors. Subjects who are participating in the Glycemic Index study (IRB #7196) will be asked for voluntarily participation in the proposed study. These volunteers will undergo 1-2 hours of standardized testing. These tests will involve tasting or smelling certain foods/beverages or ingredients in foods/beverages and rating the degree of liking/disliking, intensity and flavor or odor using a validated general Labeled magnitude scale. Volunteers will also be asked to complete a food preference survey and eating inventory questionnaire, as well as provide a DNA sample from a cheek swab or blood sample. These data will then be merged with the measures of chronic disease risk factors, body composition and habitual dietary intake data generated from the Glycemic index study in order to better understand if variations in oral sensations influence food preferences and patterns and subsequently chronic disease risk.

Conditions

Cardiovascular Disease; Diabetes; Obesity; Metabolic Syndrome; Aging

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

18-49 years

Younger

No interventions assigned to this group

50-85 years

Older

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• men and women;
• aged 18 to 85 years old;
• free of known chronic disease;
• BMI < 35 kg/ m2.

Exclusion Criteria

• BMI ≥ 35 kg/m2;
• renal or liver disease;
• untreated hypertension;
• irritable bowel syndrome;
• malabsorptive, esophageal and gastrointestinal motility disorders;
• chronic pancreatitis, or history of acute pancreatitis within the last year;
• hypothyroidism or hypothyroidism, as defined as screening TSH outside of normal ranges;
• anemia, as defined by screening hematocrit of 34% for women and 38% for men;
• smoking within the past 6 months;
• diabetes;
• fasting glucose ≥ 125 mg/dL;
• pregnancy or breastfeeding;
• history of polycystic ovary syndrome;
• history of autoimmune or other connective tissue disorders associated with chronic inflammation, such as rheumatoid arthritis; alcohol consumption > 7 drinks/ week;
• use of medications known to affect glucose or lipid metabolism;
• established CVD (myocardial infarction, stroke, heart failure, coronary artery bypass, graft, stenosis > 50%, peripheral arterial disease);
• unwillingness to adhere to study protocol;
• weight gain or loss of more than 15 lbs within 6 months prior to enrollment and other abnormal screening laboratory analysis results.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 85 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Connecticut

OTHER

Sponsor Role: collaborator

Tufts University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Nirupa R Matthan, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

HNRCA at Tufts University

Locations

Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University

Boston, Massachusetts, United States

Countries

United States

References

Vega-Lopez S, Ausman LM, Griffith JL, Lichtenstein AH. Interindividual variability and intra-individual reproducibility of glycemic index values for commercial white bread. Diabetes Care. 2007 Jun;30(6):1412-7. doi: 10.2337/dc06-1598. Epub 2007 Mar 23.

Reference Type: BACKGROUND

PMID: 17384339 (View on PubMed)

He W, Sengupta M, Velkoff VA, DeBarros KA. U.S. Census Bureau, Current Population Reports, 65+ in the United States: 2005. U.S. Government Printing Office, Washington DC. 2005: 23-209.

Reference Type: BACKGROUND

Duffy VB, Chapo AK. Smell, Taste, and Somatosensation in the Elderly. Jones and Bartlett Publishers, 2006: 115-153.

Reference Type: BACKGROUND

Seiberling KA, Conley DB. Aging and olfactory and taste function. Otolaryngol Clin North Am. 2004 Dec;37(6):1209-28, vii. doi: 10.1016/j.otc.2004.06.006.

Reference Type: BACKGROUND

PMID: 15563911 (View on PubMed)

Dinehart ME, Hayes JE, Bartoshuk LM, Lanier SL, Duffy VB. Bitter taste markers explain variability in vegetable sweetness, bitterness, and intake. Physiol Behav. 2006 Feb 28;87(2):304-13. doi: 10.1016/j.physbeh.2005.10.018. Epub 2005 Dec 20.

Reference Type: BACKGROUND

PMID: 16368118 (View on PubMed)

Bartoshuk LM, Duffy VB, Hayes JE, Moskowitz HR, Snyder DJ. Psychophysics of sweet and fat perception in obesity: problems, solutions and new perspectives. Philos Trans R Soc Lond B Biol Sci. 2006 Jul 29;361(1471):1137-48. doi: 10.1098/rstb.2006.1853.

Reference Type: BACKGROUND

PMID: 16815797 (View on PubMed)

Drewnowski A. Taste preferences and food intake. Annu Rev Nutr. 1997;17:237-53. doi: 10.1146/annurev.nutr.17.1.237.

Reference Type: BACKGROUND

PMID: 9240927 (View on PubMed)

Lanier SA, Hayes JE, Duffy VB. Sweet and bitter tastes of alcoholic beverages mediate alcohol intake in of-age undergraduates. Physiol Behav. 2005 Jan 17;83(5):821-31. doi: 10.1016/j.physbeh.2004.10.004. Epub 2004 Nov 21.

Reference Type: BACKGROUND

PMID: 15639168 (View on PubMed)

Goldstein GL, Daun H, Tepper BJ. Adiposity in middle-aged women is associated with genetic taste blindness to 6-n-propylthiouracil. Obes Res. 2005 Jun;13(6):1017-23. doi: 10.1038/oby.2005.119.

Reference Type: BACKGROUND

PMID: 15976144 (View on PubMed)

Duffy VB. Associations between oral sensation, dietary behaviors and risk of cardiovascular disease (CVD). Appetite. 2004 Aug;43(1):5-9. doi: 10.1016/j.appet.2004.02.007.

Reference Type: BACKGROUND

PMID: 15262011 (View on PubMed)

Rolls BJ. Do chemosensory changes influence food intake in the elderly? Physiol Behav. 1999 Apr;66(2):193-7. doi: 10.1016/s0031-9384(98)00264-9.

Reference Type: BACKGROUND

PMID: 10336143 (View on PubMed)

Bartoshuk LM, Duffy VB, Miller IJ. PTC/PROP tasting: anatomy, psychophysics, and sex effects. Physiol Behav. 1994 Dec;56(6):1165-71. doi: 10.1016/0031-9384(94)90361-1.

Reference Type: BACKGROUND

PMID: 7878086 (View on PubMed)

Bartoshuk LM, Duffy VB, Fast K, Green BG, Prutkin K, Snyder DJ. Labeled scales (e.g. category, Likert, VAS) and across-group comparisons: what we have learned from genetic variation in taste. Food Quality and Preference 2003; 14: 125-138.

Reference Type: BACKGROUND

Green BG, Dalton P, Cowart B, Shaffer G, Rankin K, Higgins J. Evaluating the 'Labeled Magnitude Scale' for measuring sensations of taste and smell. Chem Senses. 1996 Jun;21(3):323-34. doi: 10.1093/chemse/21.3.323.

Reference Type: BACKGROUND

PMID: 8670711 (View on PubMed)

Other Identifiers

Ross Aging Initiative

Identifier Type: -

Identifier Source: org_study_id