Dietary Analyses in the Nurses' Health Study, Nurses' Health Study II, and Health Professionals Follow-Up Study
NCT ID: NCT03366532
Last Updated: 2017-12-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
289900 participants
OBSERVATIONAL
1980-08-31
2012-08-31
Brief Summary
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Detailed Description
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Study investigators sent follow-up questionnaires biennially to participants to update information on past medical history as well as lifestyle factors. Validated food frequency questionnaires (FFQs) were first sent in 1980 for the NHS, 1991 for the NHSII, and 1986 for the HPFS. Dietary assessments have been updated every 2-4 years since baseline. The FFQs collect information on average intake of each food item over the past year. It also specifies a common serving size for each item. Participants could select from one of nine intake frequency choices, ranging from less than once per month to six or more times per day. Participants also provided information on current use and dose of multivitamins and use of other vitamin supplements.
For these three cohorts, investigators repeatedly collected and updated information on several anthropometric and lifestyle factors such as weight, smoking status, alcohol use, coffee intake, and physical activity level. Information was also collected on several major risk factors.
Study subjects reported new diagnoses biennially. After obtaining permission from participants, their medical and pathological records were acquired. Study physicians blinded to questionnaire information reviewed these records to confirm diagnoses of coronary heart disease and stroke. Self-reported diabetes diagnoses are confirmed using a validated supplementary questionnaire on symptoms, blood glucose levels, and medication use. Deaths are identified through reports from next of kin, postal authorities, or by searching the National Death Index.
All investigations regarding dietary factors in relation to type 2 diabetes, cardiovascular disease, and mortality have been approved by the institutional review boards of both Brigham and Women's Hospital and Harvard T.H Chan School of Public Health.
Conditions
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Keywords
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Nurses' Health Study
The NHS began in 1976 when 121,700 female nurses aged 33-55 years and residing in the United States responded to a baseline questionnaire.
Dietary assessments
We use food frequency questionnaires to collect and update intake of foods and nutrients in observational studies. No intervention is involved.
Nurses' Health Study II
The NHSII was initiated in 1989 with the recruitment of 116,671 younger female registered nurses, 24 to 44 years of age, from 14 states
Dietary assessments
We use food frequency questionnaires to collect and update intake of foods and nutrients in observational studies. No intervention is involved.
Health Professionals Follow-Up Study
The Health Professionals Follow-up Study (HPFS) was established in 1986 and was comprised of 51,529 US male health professionals ranging in age from 40 to 75 years at enrollment from 50 states
Dietary assessments
We use food frequency questionnaires to collect and update intake of foods and nutrients in observational studies. No intervention is involved.
Interventions
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Dietary assessments
We use food frequency questionnaires to collect and update intake of foods and nutrients in observational studies. No intervention is involved.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Participants who left more than 70 of the 131 food items blank on the baseline FFQ, reported unusual total energy intake levels (\<3,347 or \>17,573 kJ/day for men, and \<2,092 or \>14,644 kJ/day for women), or had missing baseline dietary information.
* Participants who only completed the baseline questionnaire.
21 Years
ALL
Yes
Sponsors
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Harvard Medical School (HMS and HSDM)
OTHER
Harvard School of Public Health (HSPH)
OTHER
Responsible Party
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Qi Sun
Associate Professor of Medicine
References
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Belanger CF, Hennekens CH, Rosner B, Speizer FE. The nurses' health study. Am J Nurs. 1978 Jun;78(6):1039-40. No abstract available.
Rimm EB, Giovannucci EL, Willett WC, Colditz GA, Ascherio A, Rosner B, Stampfer MJ. Prospective study of alcohol consumption and risk of coronary disease in men. Lancet. 1991 Aug 24;338(8765):464-8. doi: 10.1016/0140-6736(91)90542-w.
Ma L, Liu G, Sampson L, Willett WC, Hu FB, Sun Q. Dietary glucosinolates and risk of type 2 diabetes in 3 prospective cohort studies. Am J Clin Nutr. 2018 Apr 1;107(4):617-625. doi: 10.1093/ajcn/nqy003.
Related Links
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Nurses' Health Studies
Other Identifiers
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2000-P-002221
Identifier Type: -
Identifier Source: org_study_id