Impact of Slowly Digestible Carbohydrates on the Gut-brain Axis

NCT ID: NCT05349903

Last Updated: 2022-04-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-11-10

Study Completion Date

2022-02-24

Brief Summary

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Our laboratory is investigating the physiological outcomes and health benefits of the consumption of high-quality carbohydrates. One important aspect of the high-quality carbohydrate characteristics is a slow and sustained digestion and glucose release to the blood. In the proposed study, the investigators will evaluate the consumption of different types of slowly digestible carbohydrates (SDCs) and their beneficial effects including moderation of the glycemic response profile (postprandial glycemic response, PPGR) and stimulation of the gut-brain axis, which controls appetite and food intake. This stimulation will be evaluated in terms of second-meal food intake and the circulatory level of appetite-suppressing gut hormones (such as glucagon-like peptide-1).

Detailed Description

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Conditions

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Appetitive Behavior Obesity Diabetes Mellitus, Type 2

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Rice flour

Rapidly digestible control

Group Type EXPERIMENTAL

Rice flour

Intervention Type OTHER

Rice flour made into rice porridge will be tested for postprandial glycemic response, gut hormone levels, gastric emptying rate, appetitive response, and fermentability.

Alternanoligosaccharide 15

Group Type EXPERIMENTAL

Alternanoligosaccharide 15

Intervention Type OTHER

Alternanoligosaccharide 15 incorporated into rice porridge will be tested for postprandial glycemic response, gut hormone levels, gastric emptying rate, appetitive response, and fermentability.

Waxy potato starch

Group Type EXPERIMENTAL

Waxy potato starch

Intervention Type OTHER

Retrograded waxy potato starch made into porridge meal will be tested for postprandial glycemic response, gut hormone levels, gastric emptying rate, appetitive response, and fermentability.

Combination of waxy potato starch and epigallocatechin gallate (EGCG)

Group Type EXPERIMENTAL

Waxy potato starch + epigallocatechin gallate (EGCG)

Intervention Type OTHER

A combination of retrograded waxy potato starch and EGCG made into porridge meal will be tested for postprandial glycemic response, gut hormone levels, gastric emptying rate, appetitive response, and fermentability.

Combination of chickpea flour and epigallocatechin gallate (EGCG)

Group Type EXPERIMENTAL

Chickpea flour + epigallocatechin gallate (EGCG)

Intervention Type OTHER

A combination of chickpea flour and EGCG made into porridge meal will be tested for postprandial glycemic response, gut hormone levels, gastric emptying rate, appetitive response, and fermentability.

Inulin

Group Type EXPERIMENTAL

Inulin

Intervention Type OTHER

Inulin incorporated into rice porridge will be tested for postprandial glycemic response, gut hormone levels, gastric emptying rate, appetitive response, and fermentability.

Interventions

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Rice flour

Rice flour made into rice porridge will be tested for postprandial glycemic response, gut hormone levels, gastric emptying rate, appetitive response, and fermentability.

Intervention Type OTHER

Alternanoligosaccharide 15

Alternanoligosaccharide 15 incorporated into rice porridge will be tested for postprandial glycemic response, gut hormone levels, gastric emptying rate, appetitive response, and fermentability.

Intervention Type OTHER

Inulin

Inulin incorporated into rice porridge will be tested for postprandial glycemic response, gut hormone levels, gastric emptying rate, appetitive response, and fermentability.

Intervention Type OTHER

Waxy potato starch

Retrograded waxy potato starch made into porridge meal will be tested for postprandial glycemic response, gut hormone levels, gastric emptying rate, appetitive response, and fermentability.

Intervention Type OTHER

Waxy potato starch + epigallocatechin gallate (EGCG)

A combination of retrograded waxy potato starch and EGCG made into porridge meal will be tested for postprandial glycemic response, gut hormone levels, gastric emptying rate, appetitive response, and fermentability.

Intervention Type OTHER

Chickpea flour + epigallocatechin gallate (EGCG)

A combination of chickpea flour and EGCG made into porridge meal will be tested for postprandial glycemic response, gut hormone levels, gastric emptying rate, appetitive response, and fermentability.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* BMI 18.5 - 25 kg/m2
* Stable weight for the past 3 months (i.e. +/- 2..5 kg)

Exclusion Criteria

* Pregnant or nursing women
* Diabetic
* Individuals with history of gastrointestinal disease
Minimum Eligible Age

22 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Société des Produits Nestlé (SPN)

INDUSTRY

Sponsor Role collaborator

Purdue University

OTHER

Sponsor Role lead

Responsible Party

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Bruce R. Hamaker

Distinguished Professor of Food Science

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Bruce R Hamaker, PhD

Role: PRINCIPAL_INVESTIGATOR

Purdue University

Locations

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Purdue University

West Lafayette, Indiana, United States

Site Status

Countries

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United States

Other Identifiers

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IRB-2020-986

Identifier Type: -

Identifier Source: org_study_id

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