Gastric Emptying of Rice With Different Starch Properties

NCT ID: NCT03035981

Last Updated: 2017-01-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-08-31

Study Completion Date

2014-12-31

Brief Summary

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Glycemic carbohydrates are associated with metabolic disturbances, such as type II diabetes, due to rapid digestion of starch into glucose. The specific properties of starch within these foods has been studied for the purpose of slowing their digestion rate and improving related physiological outcomes, such as gastric emptying rate. The current study investigated the relationship among starch digestion, gastric emptying rate and satiety in white and brown rice.

Detailed Description

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Studies have indicated that starch-based foods with somewhat high amylose content have slower in vitro starch digestion rates, which relate to a low glycemic response. Low glycemic response is associated with delayed gastric emptying rate as well. Therefore, we hypothesized that rice with a slow starch digesting property would delay gastric emptying. White and brown rice with varying amylose contents were used in this study. A 13C-labeled octanoic acid breath test method was used to measure gastric emptying rate, and questionnaires were used to assess hunger and fullness during the testing sessions. Twelve healthy volunteers were recruited to participate in a crossover design study with six rice treatments and outcome measurements were gastric emptying and satiety assessments. One fermentable carbohydrate (fructooligosaccharide, FOS) solution was used to validate the production of breath hydrogen.

Conditions

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Appetitive Behavior

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Participants

Study Groups

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White rice, low amylose

Cooked white rice with low amylose content

Group Type EXPERIMENTAL

White rice, low amylose

Intervention Type OTHER

White and brown rice were tested for differences in gastric emptying rate and appetitive response

White rice, high amylose

Cooked white rice with high amylose content

Group Type EXPERIMENTAL

White rice, high amylose

Intervention Type OTHER

White and brown rice were tested for differences in gastric emptying rate and appetitive response

White rice, slow

Cooked white rice with slow digesting starch

Group Type EXPERIMENTAL

White rice, slow

Intervention Type OTHER

White and brown rice were tested for differences in gastric emptying rate and appetitive response

White rice, resistant

Cooked white rice with resistant starch

Group Type EXPERIMENTAL

White rice, resistant

Intervention Type OTHER

White and brown rice were tested for differences in gastric emptying rate and appetitive response

Brown rice, low amylose

Cooked brown rice with low amylose content

Group Type EXPERIMENTAL

Brown rice, low amylose

Intervention Type OTHER

White and brown rice were tested for differences in gastric emptying rate and appetitive response

Brown rice, high amylose

Cooked brown rice with high amylose content

Group Type EXPERIMENTAL

Brown rice, high amylose

Intervention Type OTHER

White and brown rice were tested for differences in gastric emptying rate and appetitive response

Fructooligosaccharide (FOS)

Fermentable carbohydrate solution

Group Type EXPERIMENTAL

Fructooligosaccharide (FOS)

Intervention Type OTHER

White and brown rice were tested for differences in gastric emptying rate and appetitive response

Interventions

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White rice, low amylose

White and brown rice were tested for differences in gastric emptying rate and appetitive response

Intervention Type OTHER

White rice, high amylose

White and brown rice were tested for differences in gastric emptying rate and appetitive response

Intervention Type OTHER

White rice, slow

White and brown rice were tested for differences in gastric emptying rate and appetitive response

Intervention Type OTHER

White rice, resistant

White and brown rice were tested for differences in gastric emptying rate and appetitive response

Intervention Type OTHER

Brown rice, low amylose

White and brown rice were tested for differences in gastric emptying rate and appetitive response

Intervention Type OTHER

Brown rice, high amylose

White and brown rice were tested for differences in gastric emptying rate and appetitive response

Intervention Type OTHER

Fructooligosaccharide (FOS)

White and brown rice were tested for differences in gastric emptying rate and appetitive response

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Normal body mass index (18 kg/m2 ≤ BMI ≤ 25 kg/m2)

Exclusion Criteria

* Under any medication
* History of any gastrointestinal disease or surgery
* Diabetes
* Smoker
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Purdue University

OTHER

Sponsor Role lead

Responsible Party

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Bruce R. Hamaker

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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1405014904

Identifier Type: -

Identifier Source: org_study_id

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