Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
20 participants
INTERVENTIONAL
2010-03-31
2013-02-28
Brief Summary
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10 lean and 10 obese volunteers will come 3 times (\>3 weeks apart) at the investigation center to receive a standard breakfast containing milk fat (10 g non emulsified, or 40 g non emulsified, or 40 g finely emulsified). 13C triglyceride stable isotopes will allow to follow the metabolic fate of fatty acids and calculate lipid oxidation by breath test. Blood sampling throughout digestion will allow to measure metabolic, lipid and inflammation parameters. Stool will be analysed to determine lipid losses in faeces and to phenotype microbiota.
Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
NONE
Study Groups
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10 g non emulsified of milk fat
They are compared using the repeated measurements taken within subjects
All subjects receive three sequences of a standard breakfast
All subjects receive three sequences of a standard breakfast containing :
* 10 g non emulsified
* or 40 g non emulsified
* or 40 g finely emulsified of milk fat with stable isotope (13C triglyceride). The administration order is determined by randomized allocation. The wash-out period is three weeks. There are not diet or exercise interventions. Only, one week before and three days after, the subjects consume neither naturally enriched in 13C foods or pre/probiotics. In addition, three days before and three days after each test, the subjects receive dietary instructions
40 g non emulsified of milk fat
The subjects receive three sequences of different breakfasts. They are compared using the repeated measurements taken within subjects.
All subjects receive three sequences of a standard breakfast
All subjects receive three sequences of a standard breakfast containing :
* 10 g non emulsified
* or 40 g non emulsified
* or 40 g finely emulsified of milk fat with stable isotope (13C triglyceride). The administration order is determined by randomized allocation. The wash-out period is three weeks. There are not diet or exercise interventions. Only, one week before and three days after, the subjects consume neither naturally enriched in 13C foods or pre/probiotics. In addition, three days before and three days after each test, the subjects receive dietary instructions
40 g finely emulsified of milk fat
The subjects receive three sequences of different breakfasts. They are compared using the repeated measurements taken within subjects.
All subjects receive three sequences of a standard breakfast
All subjects receive three sequences of a standard breakfast containing :
* 10 g non emulsified
* or 40 g non emulsified
* or 40 g finely emulsified of milk fat with stable isotope (13C triglyceride). The administration order is determined by randomized allocation. The wash-out period is three weeks. There are not diet or exercise interventions. Only, one week before and three days after, the subjects consume neither naturally enriched in 13C foods or pre/probiotics. In addition, three days before and three days after each test, the subjects receive dietary instructions
Interventions
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All subjects receive three sequences of a standard breakfast
All subjects receive three sequences of a standard breakfast containing :
* 10 g non emulsified
* or 40 g non emulsified
* or 40 g finely emulsified of milk fat with stable isotope (13C triglyceride). The administration order is determined by randomized allocation. The wash-out period is three weeks. There are not diet or exercise interventions. Only, one week before and three days after, the subjects consume neither naturally enriched in 13C foods or pre/probiotics. In addition, three days before and three days after each test, the subjects receive dietary instructions
Eligibility Criteria
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Inclusion Criteria
* BMI 18 to 35 kg/m2
* Moderate physical activity
* Safety subject during medical consultation
Exclusion Criteria
* Drug use that could affect lipid metabolism and gut microflora (steroids, antilipemic agent, anorectic, antibiotic)
* Inflammatory or infectious disease in the last three month
* C Reactive Protein \> 20
* Prebiotic or probiotic high consumers (several times a day)
* Eating disorder
* Claustrophobic subjects
18 Years
45 Years
MALE
Yes
Sponsors
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Hospices Civils de Lyon
OTHER
Responsible Party
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Hospices Civils de Lyon, Centre de Recherche en Nutrition Humaine -Rhône-Alpes,
Locations
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Hospices Civils de Lyon,Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA)
Lyon, 165 Chemin Du Grand Revoyet, France
Countries
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Central Contacts
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Facility Contacts
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Stéphanie Lambert-Porcheron, Dr.
Role: primary
References
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Vors C, Drai J, Pineau G, Laville M, Vidal H, Laugerette F, Michalski MC. Emulsifying dietary fat modulates postprandial endotoxemia associated with chylomicronemia in obese men: a pilot randomized crossover study. Lipids Health Dis. 2017 May 25;16(1):97. doi: 10.1186/s12944-017-0486-6.
Vors C, Pineau G, Drai J, Meugnier E, Pesenti S, Laville M, Laugerette F, Malpuech-Brugere C, Vidal H, Michalski MC. Postprandial Endotoxemia Linked With Chylomicrons and Lipopolysaccharides Handling in Obese Versus Lean Men: A Lipid Dose-Effect Trial. J Clin Endocrinol Metab. 2015 Sep;100(9):3427-35. doi: 10.1210/JC.2015-2518. Epub 2015 Jul 7.
Vors C, Drai J, Gabert L, Pineau G, Laville M, Vidal H, Guichard E, Michalski MC, Feron G. Salivary composition in obese vs normal-weight subjects: towards a role in postprandial lipid metabolism? Int J Obes (Lond). 2015 Sep;39(9):1425-8. doi: 10.1038/ijo.2015.71. Epub 2015 Apr 28.
Vors C, Pineau G, Gabert L, Drai J, Louche-Pelissier C, Defoort C, Lairon D, Desage M, Danthine S, Lambert-Porcheron S, Vidal H, Laville M, Michalski MC. Modulating absorption and postprandial handling of dietary fatty acids by structuring fat in the meal: a randomized crossover clinical trial. Am J Clin Nutr. 2013 Jan;97(1):23-36. doi: 10.3945/ajcn.112.043976. Epub 2012 Dec 12.
Related Links
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Related Info
Other Identifiers
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2009.563/16
Identifier Type: -
Identifier Source: org_study_id