Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
50 participants
INTERVENTIONAL
2014-08-31
2015-09-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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Control drink
An isocaloric drink to milk
Placebo
Milk
Protein enriched milk (Styrk)
Milk
4 dl milk will be consumed daily with breakfast and supper for 12 weeks
Interventions
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Milk
4 dl milk will be consumed daily with breakfast and supper for 12 weeks
Placebo
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* reduced gait speed or
* reduced "five times sit to stand test" or
* reduced "timed step stair test " or
* reduced grip strength
* Stable body weight (last 3 months)
* Mini Nutritional Assessment (MNA®) score ≥ 17
* Mini-mental status (MMSE-NR) score: ≥ 24
* Willing to participate according to the protocol
Exclusion Criteria
* High intake of milk and yoghurt
* Physical active subjects
* Known diabetes type I or II, or HbA1c ≥ 6,5%
* Recent events of acute cardiovascular disease including stroke
* Rapidly evolving diseases (active malignancy) or history of cancer (malignant tumors) last 3 years.
* Severe inflammation-related diseases such as e.g. Crohn disease and arthritis
* Chronic obstructive pulmonary disease
* Increased blood pressure
* High intake of alcohol
* Reduced kidney function (GFR \< 45 ml/min)
* Increased hsCRP, ASAT, ALAT
* Increased or suppressed TSH
* Hormone therapy
* Systemic use of glucocorticosteroids (anti-inflammatory steroid hormones). Use of spray and inhalator use is not exclusion.
* Disability preventing physical tests
* Using medications known to affect protein metabolism
70 Years
ALL
Yes
Sponsors
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The Research Council of Norway
OTHER
Tine
INDUSTRY
Oslo Metropolitan University
OTHER
Norwegian School of Sport Sciences
OTHER
University of Oslo
OTHER
Responsible Party
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Kirsten Holven
Professor
Principal Investigators
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Kirsten Holven, Professor
Role: PRINCIPAL_INVESTIGATOR
Institute of Basic Medical Sciences, Faculty of medicine, University of Oslo
Locations
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University of Oslo
Oslo, Post Box 1046, Blindern, Norway
Countries
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References
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Gjevestad GO, Holven KB, Rundblad A, Flatberg A, Myhrstad M, Karlsen K, Mutt SJ, Herzig KH, Ottestad I, Ulven SM. Increased protein intake affects pro-opiomelanocortin (POMC) processing, immune function and IGF signaling in peripheral blood mononuclear cells of home-dwelling old subjects using a genome-wide gene expression approach. Genes Nutr. 2019 Nov 28;14:32. doi: 10.1186/s12263-019-0654-6. eCollection 2019.
Ottestad I, Lovstad AT, Gjevestad GO, Hamarsland H, Saltyte Benth J, Andersen LF, Bye A, Biong AS, Retterstol K, Iversen PO, Raastad T, Ulven SM, Holven KB. Intake of a Protein-Enriched Milk and Effects on Muscle Mass and Strength. A 12-Week Randomized Placebo Controlled Trial among Community-Dwelling Older Adults. J Nutr Health Aging. 2017;21(10):1160-1169. doi: 10.1007/s12603-016-0856-1.
Other Identifiers
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2014/150/REK sør-øst C
Identifier Type: -
Identifier Source: org_study_id
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