The Effect of Bovine Colostrum Supplementation in Older Adults

NCT ID: NCT01792297

Last Updated: 2017-05-05

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 40 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2012-12-31
• Study Completion Date: 2013-02-28

Brief Summary

Bovine colostrum is the initial milk secreted by cows during the first day after calving. Colostrum is high in protein and contains a number of substances that have potential to be beneficial for the immune system. Preliminary studies about effects of colostrum supplementation show its potential for increasing human exercise performance; however, more evidence across the lifespan is required to confirm effects and to understand mechanisms of action. The objectives are to determine the effect of 8 weeks of bovine colostrum supplementation, compared to whey protein supplementation on the following dependent variables in men and women 50 years and older while participating in a resistance-training program:

• muscle mass
• strength
• blood levels of growth factors and markers of inflammation
• urine levels of muscle and bone catabolic markers
• tests of cognitive ability It is hypothesized that bovine colostrum supplementation will result in greater increases in muscle mass, strength, blood IGF-1 levels (an anabolic hormone), and cognitive ability, and greater reductions in inflammation, and markers of muscle and bone catabolism, compared to placebo.

Conditions

Sarcopenia; Osteoporosis

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: QUADRUPLE

Study Groups

Bovine Colostrum

60 g/d bovine colostrum in powder form to be mixed with drinks. The dose will be spread out 3 times per day (20 g per dose)

Group Type: EXPERIMENTAL

Bovine colostrum

Intervention Type: DIETARY_SUPPLEMENT

Whey protein

60 g/d whey protein powder mixed into drinks. It is to be divided into 3 daily doses (20 g per dose)

Group Type: ACTIVE_COMPARATOR

Whey protein

Intervention Type: DIETARY_SUPPLEMENT

Interventions

Bovine colostrum

Intervention Type: DIETARY_SUPPLEMENT

Whey protein

Intervention Type: DIETARY_SUPPLEMENT

Eligibility Criteria

Inclusion Criteria

• Men or women 50 y or older

Exclusion Criteria

• Milk allergies
• Contraindications to exercise as indicated by the Physical Activity Readiness Questionnaire

• Minimum Eligible Age: 50 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Mitacs

INDUSTRY

Sponsor Role: collaborator

University of Saskatchewan

OTHER

Sponsor Role: lead

Responsible Party

Phil Chilibeck

Ph.D.

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Philip D Chilibeck, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Saskatchewan

Locations

College of Kinesiology, University of Saskatchewan

Saskatoon, Saskatchewan, Canada

Countries

Canada

References

Antonio J, Sanders MS, Van Gammeren D. The effects of bovine colostrum supplementation on body composition and exercise performance in active men and women. Nutrition. 2001 Mar;17(3):243-7. doi: 10.1016/s0899-9007(00)00552-9.

Reference Type: BACKGROUND

PMID: 11312068 (View on PubMed)

Kerksick CM, Rasmussen C, Lancaster S, Starks M, Smith P, Melton C, Greenwood M, Almada A, Kreider R. Impact of differing protein sources and a creatine containing nutritional formula after 12 weeks of resistance training. Nutrition. 2007 Sep;23(9):647-56. doi: 10.1016/j.nut.2007.06.015.

Reference Type: BACKGROUND

PMID: 17679046 (View on PubMed)

Other Identifiers

12-255

Identifier Type: -

Identifier Source: org_study_id