Egg Cholesterol Consumption, Blood Cholesterol and Skeletal Muscle Hypertrophy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

36 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-11-30

Study Completion Date

2018-01-31

Brief Summary

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The purpose of this study is to examine the effect of dietary cholesterol administered as whole egg or egg white (control)on muscle mass gain with resistance training in a young old population of men and women (age 50-69). It is hypothesized that dietary cholesterol will be significantly associated to muscle mass gain.

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Detailed Description

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The primary objective of this proposal is to have 36 men and women (age 50-69) perform 12 weeks of resistance exercise training for the purpose of inducing skeletal muscle hypertrophy. These individuals will consume either 0, 1, or 3 whole eggs per day in a double-blind design to test the hypothesis that dietary cholesterol is essential for skeletal muscle hypertrophy. If so proven, this will confirm a very strong association between dietary cholesterol and hypertrophy observed in a previous study of 51 men and women (age 60-69). The current proposal is using a randomized double-blind, placebo controlled design to provide the most conclusive evidence that dietary cholesterol plays an essential role in skeletal muscle hypertrophy.

The secondary objective of this proposal is to test the hypothesis that increased dietary cholesterol consumption in the context of an exercise program does not alter blood cholesterol concentrations or other cardiovascular risk factors.

Conditions

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Sarcopenia Cardiovascular Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Placebo

\< 200 mg/day dietary cholesterol, resistance training, sedentary

Group Type PLACEBO_COMPARATOR

Resistance Training

Intervention Type BEHAVIORAL

12 weeks, 3 times a week whole body resistance training

Sedentary

Intervention Type BEHAVIORAL

Absence of physical activity

Average intake

400 mg/day dietary cholesterol, resistance training, sedentary

Group Type EXPERIMENTAL

Resistance Training

Intervention Type BEHAVIORAL

12 weeks, 3 times a week whole body resistance training

Sedentary

Intervention Type BEHAVIORAL

Absence of physical activity

High intake

800 mg/day dietary cholesterol, resistance training, sedentary

Group Type EXPERIMENTAL

Resistance Training

Intervention Type BEHAVIORAL

12 weeks, 3 times a week whole body resistance training

Sedentary

Intervention Type BEHAVIORAL

Absence of physical activity

Interventions

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Resistance Training

12 weeks, 3 times a week whole body resistance training

Intervention Type BEHAVIORAL

Sedentary

Absence of physical activity

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* men and women aged 50-69
* able to perform exercise testing and training

Exclusion Criteria

* blood pressure \> 160/100
* cardiac arrhythmias
* cancer
* hernia
* aortic aneurysm
* kidney disease
* lung disease
* total cholesterol \> 240 mg/dl or \< 160 mg/dl
* current use of cholesterol lowering medications
* actively participating in \>1 hour per week of resistance training

Minimum Eligible Age

50 Years

Maximum Eligible Age

69 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes