Physiological Effects of Creatine Supplementation in Active Males

NCT ID: NCT03003988

Last Updated: 2017-01-04

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 48 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2014-09-30
• Study Completion Date: 2014-12-31

Brief Summary

This study was designed to examine how different forms of creatine impact active males.

Detailed Description

This study examined the effects of different formulations of creatine nitrate on muscle creatine content, body composition, anaerobic exercise capacity, bench press performance and clinical chemistry panels in recreationally active males.

Conditions

Dietary Supplementation

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: HEALTH_SERVICES_RESEARCH
• Blinding Strategy: DOUBLE

Study Groups

Creatine monohydrate

Creatine monohydrate (6.0 g.) + dextrose (0.5 g.)

Group Type: EXPERIMENTAL

Creatine monohydrate

Intervention Type: DIETARY_SUPPLEMENT

Creatine monohydrate (6.0 g) + dextrose (0.5 g)

Creatine nitrate

Creatine nitrate (5.0 g. creatine monohydrate + 1.5 g. creatine nitrate that provides 1.0 g. of creatine and 0.5 g. nitrate in 2:1 ratio).

Group Type: ACTIVE_COMPARATOR

Creatine nitrate

Intervention Type: DIETARY_SUPPLEMENT

Creatine nitrate (5.0 g creatine monohydrate + 1.5 g. creatine nitrate that provides 1.0 g. of creatine and 0.5 g. nitrate in 2:1 ratio)

Placebo

6.5 g. dextrose

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: DIETARY_SUPPLEMENT

Placebo (6.5 g dextrose)

Interventions

Creatine monohydrate

Creatine monohydrate (6.0 g) + dextrose (0.5 g)

Intervention Type: DIETARY_SUPPLEMENT

Creatine nitrate

Creatine nitrate (5.0 g creatine monohydrate + 1.5 g. creatine nitrate that provides 1.0 g. of creatine and 0.5 g. nitrate in 2:1 ratio)

Intervention Type: DIETARY_SUPPLEMENT

Placebo

Placebo (6.5 g dextrose)

Intervention Type: DIETARY_SUPPLEMENT

Eligibility Criteria

Inclusion Criteria

• participants are apparently healthy and recreationally active males between the ages of 18 and 40;
• participants will need to have at least six months immediate prior history of resistance training on the bench press and leg press or squat;

Exclusion Criteria

• participants have a history of treatment for metabolic disease (i.e., diabetes), hypertension, hypotension, thyroid disease, arrhythmias and/or cardiovascular disease;
• participants are currently using prescription medications;
• participants have a history of smoking;
• participants drink excessively (i.e., 12 drinks per week or more);
• participants have a recent history of creatine supplementation within six weeks of the start of supplementation;

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Nutrabolt

INDUSTRY

Sponsor Role: collaborator

Texas A&M University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Richard B Kreider, PhD

Role: PRINCIPAL_INVESTIGATOR

Texas A&M University

Other Identifiers

IRB2014-0503FX

Identifier Type: -

Identifier Source: org_study_id