Effects of Betaine Supplementation on Strength and Muscle Creatine Content

NCT ID: NCT01213719

Last Updated: 2012-01-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-10-31

Study Completion Date

2011-07-31

Brief Summary

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It has been suggested that betaine supplementation may improve muscle strength by increasing muscle creatine content. However, there is no data supporting this assumption. The investigators speculate that betaine supplementation could enhance intramuscular creatine content, which would result in strength improvements.

Detailed Description

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Conditions

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Healthy Subjects

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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creatine

will receive creatine monohydrate (20g/d) throughout 10 days

Group Type EXPERIMENTAL

creatine

Intervention Type DIETARY_SUPPLEMENT

20g/d throughout 10 days

betaine

will receive betaine (2g/d) throughout 10 days

Group Type EXPERIMENTAL

betaine

Intervention Type DIETARY_SUPPLEMENT

2g/d throughout 10 days

placebo (dextrose)

will receive dextrose(20g/d)throughout 10 days.

Group Type PLACEBO_COMPARATOR

dextrose

Intervention Type DIETARY_SUPPLEMENT

dextrose (placebo), 20 g/d throughout 10 days

creatine plus betaine

will receive creatine (20g/d) plus betaine (2g/d) throughout 10 days

Group Type ACTIVE_COMPARATOR

creatine plus betaine

Intervention Type DIETARY_SUPPLEMENT

creatine (20g/d) plus betaine (2g/d) throughout 10 days

Interventions

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creatine

20g/d throughout 10 days

Intervention Type DIETARY_SUPPLEMENT

betaine

2g/d throughout 10 days

Intervention Type DIETARY_SUPPLEMENT

dextrose

dextrose (placebo), 20 g/d throughout 10 days

Intervention Type DIETARY_SUPPLEMENT

creatine plus betaine

creatine (20g/d) plus betaine (2g/d) throughout 10 days

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* physically inactive
* non-obese

Exclusion Criteria

* skeletal muscle disturbance
* cardiovascular disturbance
* use of dietary supplements
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of Sao Paulo

OTHER

Sponsor Role lead

Responsible Party

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Bruno Gualano

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Bruno Gualano, PhD

Role: STUDY_DIRECTOR

University of Sao Paulo

Locations

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University of Sao Paulo

São Paulo, São Paulo, Brazil

Site Status

Countries

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Brazil

Other Identifiers

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betaine supplementation

Identifier Type: -

Identifier Source: org_study_id

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