Milk and Milk-produce to Counteract the Loss of Muscle Mass and Function in Exercising Older Adults.

NCT ID: NCT01883674

Last Updated: 2014-12-03

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 41 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2012-05-31
• Study Completion Date: 2014-12-31

Brief Summary

This project evaluates the use of different types of proteins from various food sources after an exercise session, on muscle mass and physical capacity in aged sarcopenic men (who have low muscle mass). Specifically, researchers want to:

• Examine the efficiency of protein intake after exercise on muscle mass and physical abilities;
• Examine the impact of exercise and proteins on blood lipids (LDL cholesterol, HDL cholesterol, total cholesterol and triglycerides);
• Examine the impact of exercise and proteins on liver enzymes;
• Examine the impact of exercise and proteins on a hormone that controls hunger;
• Evaluate the program's impact on the ability of the body to produce energy.

All participants are exercising (resistance training) and ingest one of the 3 different sources of proteins, immediately after training:

• Milk proteins (from milk beverage)
• Essential amino acids (added to a soya beverage)
• No protein (rice beverage - control group)

Our hypothesis is that proteins from milk will induce a gain in muscle mass and physical function equivalent to the essential amino acids (EAA). We anticipate that both milk proteins and EAA will be both superior to control group.

This would represent an interesting finding since milk is more accessible, palatable and cheaper than essential amino acids commercial mix.

Conditions

Sarcopenia

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: QUADRUPLE

Study Groups

Milk proteins

This group will do a resistance training + milk proteins (milk beverage)

Group Type: EXPERIMENTAL

Resistance training

Intervention Type: OTHER

All group will exercise 3x/week. Each session of resistance training will last 60min. and will target main muscular groups.

Essential amino acids (add to soya bvg)

This group will do a resistance training + essential amino acids (added to soya beverage)

Group Type: EXPERIMENTAL

Resistance training

Intervention Type: OTHER

All group will exercise 3x/week. Each session of resistance training will last 60min. and will target main muscular groups.

No protein (control)

This group will do a resistance training + ingestion of the control beverage (no protein, rice beverage)

Group Type: PLACEBO_COMPARATOR

Resistance training

Intervention Type: OTHER

All group will exercise 3x/week. Each session of resistance training will last 60min. and will target main muscular groups.

Interventions

Resistance training

All group will exercise 3x/week. Each session of resistance training will last 60min. and will target main muscular groups.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• 65-75 years
• francophone or understanding French
• muscle mass index < 10.75 kg/m2 (Janssen et al, 2004)
• body mass index <30kg/m²
• weight stable (< 2 kg) for 6 mo
• no resistance exercise for 3 years
• controlled blood pressure for at least 6 months

Exclusion Criteria

• major physical disability
• medical treatment influencing metabolism
• statin treatment
• diagnosis or any sign of kidney disease

• Minimum Eligible Age: 65 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Dairy Farmers of Canada

OTHER

Sponsor Role: collaborator

Université de Sherbrooke

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Isabelle J. Dionne, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Université de Sherbrooke

Locations

Centre de recherche sur le vieillissement

Sherbrooke, Quebec, Canada

Countries

Canada

Other Identifiers

PLC-021742

Identifier Type: -

Identifier Source: org_study_id