High Intensity Cycling Before SCUBA Diving Reduces Post-decompression Microparticle Production and Neutrophil Activation

NCT ID: NCT02064361

Last Updated: 2014-02-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-02-28

Study Completion Date

2013-05-31

Brief Summary

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The purpose of this study is to determine the impact of high intensity,anaerobic exercise, in the form of cycling, on SCUBA diving. Outcomes are determined by the quantification and subtype of circulating microparticles, complete blood counts, and the quantification of venous gas emboli, measured via transthoracic echocardiography, in the cardiac cavities.

Detailed Description

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Conditions

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Decompression Sickness SCUBA Diving

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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High intensity exercise

A dive to 18 meters sea water for a duration of 41 minutes preceded by high intensity cycling

Group Type EXPERIMENTAL

High intensity exercise

Intervention Type OTHER

Subjects performed a repeated Wingate protocol for the exercise condition of the study. This consisted of 4, 30 s maximal efforts on a weight-braked cycle ergometer (Monark 894E, Monark Exercise AB, Sweden) with 4 min active recovery between efforts, preceded by a 5 min warm up. The resistance was set at 7.5% bodyweight for the intervals and 2% for the warm up and active recovery periods.

Interventions

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High intensity exercise

Subjects performed a repeated Wingate protocol for the exercise condition of the study. This consisted of 4, 30 s maximal efforts on a weight-braked cycle ergometer (Monark 894E, Monark Exercise AB, Sweden) with 4 min active recovery between efforts, preceded by a 5 min warm up. The resistance was set at 7.5% bodyweight for the intervals and 2% for the warm up and active recovery periods.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Experienced divers (\> 250 logged dives)
* Male
* Physician clearance to dive

Exclusion Criteria

* Prior incidence of decompression sickness
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of Maryland

OTHER

Sponsor Role collaborator

University Hospital of Split

OTHER

Sponsor Role lead

Responsible Party

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Zeljko Dujic

Professor Zeljko Dujic MD, PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Zeljko Dujic, MD. PhD

Role: PRINCIPAL_INVESTIGATOR

University Hospital of Split

Locations

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University of Maryland

Baltimore, Maryland, United States

Site Status

University of Split School of Medicine

Split, Dalmatia, Croatia

Site Status

Countries

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United States Croatia

References

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Thom SR, Milovanova TN, Bogush M, Yang M, Bhopale VM, Pollock NW, Ljubkovic M, Denoble P, Madden D, Lozo M, Dujic Z. Bubbles, microparticles, and neutrophil activation: changes with exercise level and breathing gas during open-water SCUBA diving. J Appl Physiol (1985). 2013 May 15;114(10):1396-405. doi: 10.1152/japplphysiol.00106.2013. Epub 2013 Mar 14.

Reference Type BACKGROUND
PMID: 23493363 (View on PubMed)

Other Identifiers

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SCUBACYC

Identifier Type: -

Identifier Source: org_study_id

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