Hydrogen Inhalation for Health and Exercise Performance

NCT ID: NCT03846141

Last Updated: 2019-02-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-01-15

Study Completion Date

2018-09-15

Brief Summary

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In this randomized double-blind, placebo-controlled, crossover pilot trial, we evaluated the effects of 7-day H2 inhalation on exercise performance outcomes and serum hormonal and inflammation profiles in a cohort of young men and women.

Detailed Description

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All participants were allocated to receive either gaseous hydrogen (4%) or placebo (room air) by 20-min once-per-day inhalation for 7 days, with wash-out period of 7 days to prevent the residual effects of interventions across study periods. The primary treatment outcome was the change in running time-to-exhaustion from baseline to day 7. Additionally, assessment of other exercise performance endpoints and clinical chemistry biomarkers were performed at baseline and after 7 days after each intervention.

Conditions

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Exercise Performance

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Placebo

Room air for inhalation

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

Inhalation of room air for 20 min per day during 7 days

Hydrogen

Hydrogen (4%) for inhalation

Group Type EXPERIMENTAL

Hydrogen

Intervention Type OTHER

Inhalation of 4% hydrogen for 20 min per day during 7 days

Interventions

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Placebo

Inhalation of room air for 20 min per day during 7 days

Intervention Type OTHER

Hydrogen

Inhalation of 4% hydrogen for 20 min per day during 7 days

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

Age ≥ 18 -35 years Body mass index 20 - 25 kg/m2 Free of major diseases Physically active Must be able to give written informed consent

Exclusion Criteria

Use of any dietary supplements within 4 weeks before study commences Abnormal values for lab clinical chemistry (\> 2 SD)
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Novi Sad, Faculty of Sport and Physical Education

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Sergej Ostojic, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Novi Sad

Locations

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FSPE Applied Bioenergetics Lab

Novi Sad, Vojvodina, Serbia

Site Status

Countries

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Serbia

References

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Aoki K, Nakao A, Adachi T, Matsui Y, Miyakawa S. Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes. Med Gas Res. 2012 Jul 12;2:12. doi: 10.1186/2045-9912-2-12. eCollection 2012.

Reference Type BACKGROUND
PMID: 22520831 (View on PubMed)

Ostojic SM. Serum alkalinization and hydrogen-rich water in healthy men. Mayo Clin Proc. 2012 May;87(5):501-2. doi: 10.1016/j.mayocp.2012.02.008. No abstract available.

Reference Type BACKGROUND
PMID: 22560529 (View on PubMed)

Da Ponte A, Giovanelli N, Nigris D, Lazzer S. Effects of hydrogen rich water on prolonged intermittent exercise. J Sports Med Phys Fitness. 2018 May;58(5):612-621. doi: 10.23736/S0022-4707.17.06883-9. Epub 2017 Apr 26.

Reference Type BACKGROUND
PMID: 28474871 (View on PubMed)

Javorac D, Stajer V, Ratgeber L, Betlehem J, Ostojic S. Short-term H2 inhalation improves running performance and torso strength in healthy adults. Biol Sport. 2019 Dec;36(4):333-339. doi: 10.5114/biolsport.2019.88756. Epub 2019 Oct 31.

Reference Type DERIVED
PMID: 31938004 (View on PubMed)

Other Identifiers

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UniversityNSFSandPE

Identifier Type: -

Identifier Source: org_study_id

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