Oral Nitrite Synthesis and Post-exercise Hypotension

NCT ID: NCT03904394

Last Updated: 2019-04-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

23 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-05-09

Study Completion Date

2019-03-11

Brief Summary

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Exercise is probably the most effective approach to reduce blood pressure. In fact, a single bout of exercise induces a physiological response known as Post-Exercise Hypotension (PEH) where a prolonged decrease in resting blood pressure occurs in the minutes and hours after exercise. However, it is not fully understood how this response triggers. Recent evidence suggests that oral bacteria may play a key role in blood pressure control by enhancing nitrite, and then nitric oxide (NO) bioavailability under resting conditions in humans. However, no previous study has investigated whether this is a key mechanism involve in PEH. Thus, the main aim of this study was to investigate if the oral nitrate/nitrite pathway is a key regulator of PEH and vasodilation in healthy humans.

Detailed Description

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Conditions

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Blood Pressure Sports Physical Therapy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Placebo Mouthwash

Group Type PLACEBO_COMPARATOR

Exercise

Intervention Type OTHER

Four sets of 7 minutes at 65% of VO2peak interspersed with 3 min of passive recovery

Antibacterial Mouthwash

Group Type ACTIVE_COMPARATOR

Exercise

Intervention Type OTHER

Four sets of 7 minutes at 65% of VO2peak interspersed with 3 min of passive recovery

Interventions

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Exercise

Four sets of 7 minutes at 65% of VO2peak interspersed with 3 min of passive recovery

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

Blood pressure (SBP \< 130 mmHg; DBP \< 90 mmHg) BMI \< 30 kg/m2 Age 18 to 50 years old

Exclusion Criteria

Smoker Hypertension Dyslipidaemia Diabetes Gingivitis or periodontitis Using antibacterial mouthwash or tongue scrapes Taking antibiotics 1 month before the start of the study Females without have irregular menstrual periods
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Plymouth

OTHER

Sponsor Role lead

Responsible Party

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Raul Bescos

Director

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Crai Cutler, MSc

Role: PRINCIPAL_INVESTIGATOR

University of Plymouth

Locations

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Laboratory of Nutrition, Exercise & Health

Plymouth, Devon, United Kingdom

Site Status

Countries

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United Kingdom

Other Identifiers

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(16/17)-666

Identifier Type: -

Identifier Source: org_study_id

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