Influence of Sodium Bicarbonate on Time-to-exhaustion at Critical Power in Endurance Athletes

NCT ID: NCT01621074

Last Updated: 2013-04-12

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 12 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2011-10-31
• Study Completion Date: 2013-01-31

Brief Summary

During endurance exercise in the heavy and severe intensity domains, the rate at which metabolites that have been associated with the fatigue process (e.g. Pi, ADP, H, and extracellular K) accumulate increases. possibly leading to exercise cessation. Sodium bicarbonate, as a nutritional supplement, has gained attention over the past decades, because it might delay of offset fatigue. To date, there is a controversial discussion about which delivery mode (amount and frequency) might be best in optimizing endurance performance. Since the high ion load consequent to multiple ingestions might increase plasma volume, and consequently decrease bicarbonate concentrations, single acute ingestion could be more beneficial. However, in multi-day competitions or tournaments it might be necessary to use the supplement on a daily basis. Here, the investigators aim at investigating the effects of single dose or multiple dose (on five consecutive days) administration of bicarbonate vs. placebo increases endurance performance and acid-base homeostasis in trained male endurance athletes.

Conditions

Performance

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Blinding Strategy: DOUBLE

Study Groups

Sodium bicarbonate

Group Type: ACTIVE_COMPARATOR

Sodium bicarbonate

Intervention Type: DIETARY_SUPPLEMENT

Ergogenic effect

Placebo

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: DIETARY_SUPPLEMENT

Placebo effect

Interventions

Sodium bicarbonate

Ergogenic effect

Intervention Type: DIETARY_SUPPLEMENT

Placebo

Placebo effect

Intervention Type: DIETARY_SUPPLEMENT

Eligibility Criteria

Inclusion Criteria

• no cold or temperature at beginning or during the study
• between 18 and 45 years of age
• active in endurance sports (3 to 5 times per week a moderate to hart training)
• non-smoker
• no known cardiovascular or orthopedic problems
• no known limitations of kidney function
• no bearer of a cardiac pacemaker
• no medications with direct influence on the measurements. The whole intake of medicaments has to be declared in the health questionnaire by the participant.
• requirements of the health questionnaire fulfilled

Exclusion Criteria

• male and age under 18 or over 45 years
• cold or temperature at the beginning or during the study
• untrained (less than 3 moderate trainings per week)
• smoker
• cardiovascular or orthopedic problems
• limitations of the kidney function
• bearer of a cardiac pacemaker
• medication with direct influence on the measurements. The whole intake of medicaments has to be declared in the health questionnaire by the participant.
• requirements of the health questionnaire not fulfilled

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: No

Sponsors

Swiss Federal Institute of Technology

OTHER

Sponsor Role: collaborator

University of Zurich

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Neurologie: Neurologische Forschung

Role: STUDY_DIRECTOR

University Hospital Zurich, Division of Neurology

Marco Toigo, PhD

Role: PRINCIPAL_INVESTIGATOR

Swiss Federal Institute of Technology Zurich

Locations

University Hospital Zurich, Division of Neurology

Zurich, Canton of Zurich, Switzerland

Countries

Switzerland

References

Mueller SM, Gehrig SM, Frese S, Wagner CA, Boutellier U, Toigo M. Multiday acute sodium bicarbonate intake improves endurance capacity and reduces acidosis in men. J Int Soc Sports Nutr. 2013 Mar 26;10(1):16. doi: 10.1186/1550-2783-10-16.

Reference Type: DERIVED

PMID: 23531361 (View on PubMed)

Other Identifiers

nbc

Identifier Type: -

Identifier Source: org_study_id