Effects of Novel Sodium Bicarbonate Ingestion of Buffering Capacity
NCT ID: NCT03813329
Last Updated: 2019-01-23
Study Results
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Basic Information
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COMPLETED
EARLY_PHASE1
10 participants
INTERVENTIONAL
2004-05-01
2005-12-31
Brief Summary
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This study was also designed to corroborate the results of previous studies regarding the ergogenic effects of sodium bicarbonate ingestion. Most studies have administered sodium bicarbonate in solutions, which would make the participants aware of the substance ingested due to the distinctive flavor of SB, possibly inducing a placebo effect. All doses in the present study were administered in gelatin capsules to mask the flavor of the ingested substances, maintaining participant blindness to the procedure.
Blood samples were collected at baseline and following placebo (CaCO3), acute sodium bicarbonate ingestion, and modified sodium bicarbonate ingestion to determine the effects of the ingestion protocols on serum bicarbonate, sodium and lactate concentrations, as well as on serum pH and blood hematocrit. The study design was a randomized double-blind crossover.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
DOUBLE
Study Groups
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Placebo
4 progressively larger doses (110 mg·kg-1 - 200 mg·kg-1) of Calcium carbonate
Modified Sodium Bicarbonate
4 progressively larger doses (110 mg·kg-1 - 200 mg·kg-1) of sodium bicarbonate
Acute Sodium Bicarbonate
3 progressively larger doses of calcium carbonate followed by one acute dose of sodium bicarbonate (300 mg/kg)
Calcium carbonate (placebo)
4 progressively larger doses (110 mg·kg-1 - 200 mg·kg-1) of calcium carbonate
Acute Sodium Bicarbonate
3 doses of calcium carbonate (110 mg·kg-1, 130 mg·kg-1, 160 mg·kg-1), followed by one acute does (300 mg·kg-1) of sodium bicarbonate.
Modified Sodium Bicarbonate
4 progressively larger doses (110 mg·kg-1 - 200 mg·kg-1) of sodium bicarbonate
Acute Sodium Bicarbonate
3 progressively larger doses of calcium carbonate followed by one acute dose of sodium bicarbonate (300 mg/kg)
Calcium carbonate (placebo)
4 progressively larger doses (110 mg·kg-1 - 200 mg·kg-1) of calcium carbonate
Modified Sodium Bicarbonate
4 progressively larger doses (110 mg·kg-1 - 200 mg·kg-1) of sodium bicarbonate
Modified Sodium Bicarbonate
4 progressively larger doses (110 mg·kg-1 - 200 mg·kg-1) of sodium bicarbonate
Acute Sodium Bicarbonate
3 progressively larger doses of calcium carbonate followed by one acute dose of sodium bicarbonate (300 mg/kg)
Calcium carbonate (placebo)
4 progressively larger doses (110 mg·kg-1 - 200 mg·kg-1) of calcium carbonate
Interventions
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Modified Sodium Bicarbonate
4 progressively larger doses (110 mg·kg-1 - 200 mg·kg-1) of sodium bicarbonate
Acute Sodium Bicarbonate
3 progressively larger doses of calcium carbonate followed by one acute dose of sodium bicarbonate (300 mg/kg)
Calcium carbonate (placebo)
4 progressively larger doses (110 mg·kg-1 - 200 mg·kg-1) of calcium carbonate
Eligibility Criteria
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Inclusion Criteria
* Currently training; defined as at least 5 days·week-1 of running
* Elite-level performance (750 or more points on the International Associations of Athletics Federations Scoring Table) for an 800m-5000m race during the preceding 6 months.
Exclusion Criteria
18 Years
ALL
Yes
Sponsors
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California State University, Los Angeles
OTHER
Long Island University
OTHER
Responsible Party
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Amerigo Rossi
Assistant Professor
References
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Marcus A, Rossi A, Cornwell A, Hawkins SA, Khodiguian N. The effects of a novel bicarbonate loading protocol on serum bicarbonate concentration: a randomized controlled trial. J Int Soc Sports Nutr. 2019 Sep 18;16(1):41. doi: 10.1186/s12970-019-0309-4.
Other Identifiers
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Rossi01
Identifier Type: -
Identifier Source: org_study_id
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