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Airway Dysfunction and Remodelling in Athletes Following Swimming Training in Chlorinated Pools

NCT ID: NCT00686452

Last Updated: 2008-12-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-03-31

Study Completion Date

2009-05-31

Brief Summary

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Swimmers show the highest prevalence of asthma among elite athletes, certainly due to chlorine exposure. The consequences of a chronic exposure to chlorine compounds by swimmers and the mechanisms of asthme in this population are still poorly documented. Specific diagnostic criteria have been proposed by the International Olympic Committee - Medical Council (IOC-MC) and World anti-doping agency (WADA) to determine the presence of asthma in athletes. Using the more specific bronchial provocation tests, our aims are

1. to compare the prevalence of asthma in swimmers and control subjects
2. to analyze the Influence of chlorine exposure on bronchial inflammatory processes in swimmers versus control subjects
3. to study the time-course of changes in airway symptoms, responsiveness, inflammation and remodeling after cessation of training

Detailed Description

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Conditions

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Asthma Airway Hyperresponsiveness

Keywords

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Asthma Airway hyperresponsiveness Swimmers Airway inflammation Airway remodelling

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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1

Swimmers without AHR

No interventions assigned to this group

2

Swimmers with asymptomatic AHR

No interventions assigned to this group

3

Swimmers with symptomatic AHR and use only of beta-2 adrenargic

No interventions assigned to this group

4

Swimmers with asthma and inhaled corticosteroids

No interventions assigned to this group

5

Healthy Subjects

No interventions assigned to this group

6

Healthy subjects with AHR

No interventions assigned to this group

7

Healthy subjects with symptomatic AHR (asthma) but without treatment

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* 14 to 35 years old
* To swim at least 10h per week
* For control subjects, non-competitive healthy subjects

Exclusion Criteria

* any disease that may interfere with the tests for the controls
* Triathletes are excluded
* Smokers
* Obese or with a BMI more than 29
* Former athletes (control group)
Minimum Eligible Age

14 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Laval University

OTHER

Sponsor Role lead

Responsible Party

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Hôpital Laval

Locations

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Centre de recherche en pneumologie et en cardiologie de l'hôpital Laval

Québec, Quebec, Canada

Site Status RECRUITING

Countries

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Canada

Central Contacts

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Valérie BOUGAULT, PhD

Role: CONTACT

Phone: 418-656-8711

Email: [email protected]

Louis-Philippe BOULET, MD

Role: CONTACT

Phone: 418-656-4747

Email: [email protected]

Facility Contacts

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Valerie BOUGAULT, PhD

Role: primary

Louis-Philippe BOULET, MD

Role: backup

References

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Bougault V, Odashiro P, Turmel J, Orain M, Laviolette M, Joubert P, Boulet LP. Changes in airway inflammation and remodelling in swimmers after quitting sport competition. Clin Exp Allergy. 2018 Dec;48(12):1748-1751. doi: 10.1111/cea.13257. Epub 2018 Sep 14. No abstract available.

Reference Type DERIVED
PMID: 30141830 (View on PubMed)

Bougault V, Turmel J, Boulet LP. Bronchial challenges and respiratory symptoms in elite swimmers and winter sport athletes: Airway hyperresponsiveness in asthma: its measurement and clinical significance. Chest. 2010 Aug;138(2 Suppl):31S-37S. doi: 10.1378/chest.09-1689. Epub 2010 Apr 2.

Reference Type DERIVED
PMID: 20363843 (View on PubMed)

Other Identifiers

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CER20159

Identifier Type: -

Identifier Source: org_study_id