Nutritional Evaluation of Canola Protein in Comparison With Soy Protein
NCT ID: NCT01481584
Last Updated: 2015-03-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
28 participants
INTERVENTIONAL
2010-05-31
2011-11-30
Brief Summary
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Detailed Description
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Twenty-eight healthy men (ø 25 years) completed a double-blind, placebo-controlled, crossover study. The subjects were randomly divided into two groups (group A: canola protein isolate and soy protein isolate and group B: canola protein hydrolyzate and soy protein isolate). After a three-day run-in period, on the intervention day, the subjects consumed a protein drink containing 30.0 g protein powder added to a final volume of 500 mL tomato juice. Half of the subjects in each group consumed a protein drink containing 30.0 g canola protein, the other half received the soy protein. After taking of fasting blood samples in the morning of the intervention day, blood samples were drawn at regular intervals for a period of eight hours. At the end of the run-in period and on the intervention day, a 24-hour urine collection took place.
Within a second experiment (after 4 weeks), the protein source was crossed within the four subgroups for the second intervention.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
SCREENING
QUADRUPLE
Study Groups
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Canola protein
Canola protein (Brassica juncea; incorporated in a drink)
Protein drink - protein isolate
The subjects consumed 500 mL of a protein drink (tomato juice) containing 30 g protein (canola protein isolate or reference protein) after overnight fasting. After run-in period, each volunteer have to pass both protein-intervention days in different order with a four-week wash out period in between.
Protein drink - protein hydrolyzate
The subjects consumed 500 mL of a protein drink (tomato juice) containing 30 g protein (canola protein hydrolyzate or reference protein) after overnight fasting. After run-in period, each volunteer have to pass both protein-intervention days in different order with a four-week wash out period in between.
Reference protein
Reference Protein (soy protein isolate; incorporated in a drink)
Protein drink - protein isolate
The subjects consumed 500 mL of a protein drink (tomato juice) containing 30 g protein (canola protein isolate or reference protein) after overnight fasting. After run-in period, each volunteer have to pass both protein-intervention days in different order with a four-week wash out period in between.
Protein drink - protein hydrolyzate
The subjects consumed 500 mL of a protein drink (tomato juice) containing 30 g protein (canola protein hydrolyzate or reference protein) after overnight fasting. After run-in period, each volunteer have to pass both protein-intervention days in different order with a four-week wash out period in between.
Wash out
Wash out (four weeks without any intervention between interventional periods)
No interventions assigned to this group
Run-in
Run-in period (three days before intervention, defined diet)
No interventions assigned to this group
Interventions
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Protein drink - protein isolate
The subjects consumed 500 mL of a protein drink (tomato juice) containing 30 g protein (canola protein isolate or reference protein) after overnight fasting. After run-in period, each volunteer have to pass both protein-intervention days in different order with a four-week wash out period in between.
Protein drink - protein hydrolyzate
The subjects consumed 500 mL of a protein drink (tomato juice) containing 30 g protein (canola protein hydrolyzate or reference protein) after overnight fasting. After run-in period, each volunteer have to pass both protein-intervention days in different order with a four-week wash out period in between.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Body mass index: 20-26 kg/m²
Exclusion Criteria
* Allergy against canola protein or soy protein
* Kidney disease
20 Years
35 Years
MALE
Yes
Sponsors
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University of Jena
OTHER
Responsible Party
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Gerhard Jahreis
Prof. Dr.
Principal Investigators
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Gerhard Jahreis, Prof. Dr.
Role: PRINCIPAL_INVESTIGATOR
Friedrich Schiller University Jena, Institute of Nutrition, Department of Nutritional Physiology
Locations
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Friedrich Schiller University Jena, Department of Nutritional Physiology
Jena, Thuringia, Germany
Countries
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References
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Fleddermann M, Fechner A, Rossler A, Bahr M, Pastor A, Liebert F, Jahreis G. Nutritional evaluation of rapeseed protein compared to soy protein for quality, plasma amino acids, and nitrogen balance--a randomized cross-over intervention study in humans. Clin Nutr. 2013 Aug;32(4):519-26. doi: 10.1016/j.clnu.2012.11.005. Epub 2012 Nov 14.
Other Identifiers
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LSEP H43-10
Identifier Type: -
Identifier Source: org_study_id
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