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The Effect of Oral Intake of Animal and Plant Proteins on the Metabolism in Healthy Women

NCT ID: NCT06045611

Last Updated: 2025-08-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

28 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-10-13

Study Completion Date

2025-09-30

Brief Summary

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The goal of this interventional study is to learn about the effects of different proteins (from animals or plants) on the metabolism in healthy, normal weight women between 18-45 year who are not on hormonal birth-control.

The main questions the study aims to answer are:

1. How do different proteins affect biological markers of the metabolism and which protein has the strongest effect?
2. How are the different proteins digested and taken up from our body?

Participants will drink four different shakes on four different study days in a random order. Three of them contain each a different protein and one does not contain protein. Right before drinking the shake and on 11 timepoints after drinking the shake blood samples will be drawn.

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Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Isolated Pea Protein/Isolated Whey Protein/Isolated Faba Bean Protein/Placebo

* Study day 1: 0.6g isolated pea protein/kg/body weight + 400 ml water
* Study day 2: 0.6g isolated whey protein/kg/body weight + 400 ml water
* Study day 3: 0.6g isolated faba bean protein/kg/body weight + 400 ml water
* Study day 4: 400 ml water

The fat and energy content of the drinks will be adapted using a plant based oil

Group Type EXPERIMENTAL

Isolated Pea Protein

Intervention Type DIETARY_SUPPLEMENT

Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.

Isolated Whey Protein

Intervention Type DIETARY_SUPPLEMENT

Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.

Isolated Faba Bean Protein

Intervention Type DIETARY_SUPPLEMENT

Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.

Placebo

Intervention Type DIETARY_SUPPLEMENT

Participants will consume the placebo in an opaque mug wearing a nose clip.

Isolated Whey Protein/Placebo/Isolated Pea Protein/Isolated Faba Bean Protein

* Study day 1: 0.6g isolated whey protein/kg/body weight + 400 ml water
* Study day 2: 400 ml water
* Study day 3: 0.6g isolated pea protein/kg/body weight + 400 ml water
* Study day 4: 0.6g isolated faba bean protein/kg/body weight + 400 ml water

The fat and energy content of the drinks will be adapted using a plant based oil

Group Type EXPERIMENTAL

Isolated Pea Protein

Intervention Type DIETARY_SUPPLEMENT

Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.

Isolated Whey Protein

Intervention Type DIETARY_SUPPLEMENT

Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.

Isolated Faba Bean Protein

Intervention Type DIETARY_SUPPLEMENT

Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.

Placebo

Intervention Type DIETARY_SUPPLEMENT

Participants will consume the placebo in an opaque mug wearing a nose clip.

Isolated Faba Bean Protein/Isolated Pea Protein/Placebo/Isolated Whey Protein

* Study day 1: 0.6g isolated faba bean protein/kg/body weight + 400 ml water
* Study day 2: 0.6g isolated pea protein/kg/body weight + 400 ml water
* Study day 3: 400 ml water
* Study day 4: 0.6g isolated whey protein/kg/body weight + 400 ml water

The fat and energy content of the drinks will be adapted using a plant based oil

Group Type EXPERIMENTAL

Isolated Pea Protein

Intervention Type DIETARY_SUPPLEMENT

Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.

Isolated Whey Protein

Intervention Type DIETARY_SUPPLEMENT

Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.

Isolated Faba Bean Protein

Intervention Type DIETARY_SUPPLEMENT

Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.

Placebo

Intervention Type DIETARY_SUPPLEMENT

Participants will consume the placebo in an opaque mug wearing a nose clip.

Placebo/Isolated Faba Bean Protein/Isolated Whey Protein/Isolated Pea Protein

* Study day 1: 400 ml water
* Study day 2: 0.6g isolated faba bean protein/kg/body weight + 400 ml water
* Study day 3: 0.6g isolated whey protein/kg/body weight + 400 ml water
* Study day 4: 0.6g isolated pea protein/kg/body weight + 400 ml water

The fat and energy content of the drinks will be adapted using a plant based oil

Group Type EXPERIMENTAL

Isolated Pea Protein

Intervention Type DIETARY_SUPPLEMENT

Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.

Isolated Whey Protein

Intervention Type DIETARY_SUPPLEMENT

Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.

Isolated Faba Bean Protein

Intervention Type DIETARY_SUPPLEMENT

Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.

Placebo

Intervention Type DIETARY_SUPPLEMENT

Participants will consume the placebo in an opaque mug wearing a nose clip.

Interventions

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Isolated Pea Protein

Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.

Intervention Type DIETARY_SUPPLEMENT

Isolated Whey Protein

Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.

Intervention Type DIETARY_SUPPLEMENT

Isolated Faba Bean Protein

Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.

Intervention Type DIETARY_SUPPLEMENT

Placebo

Participants will consume the placebo in an opaque mug wearing a nose clip.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Females
* Age: 18-45 years
* Body mass index: 18.5 \< 25 kg/m2
* Signed informed consent

Exclusion Criteria

* Use of hormonal contraceptives
* Pregnancy or breastfeeding
* Diabetes mellitus or any other metabolic disease that might affect the results of this study
* Gastric surgery that affects digestion and uptake of protein
* Any clinically significant present or past disease/condition and medication which in the investigator's opinion could interfere with the results of the trial
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Örebro University, Sweden

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Örebro University

Örebro, , Sweden

Site Status

Countries

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Sweden

Other Identifiers

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Dnr 2023-03852-01

Identifier Type: -

Identifier Source: org_study_id

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