Acute Effects of Dietary Proteins on Postprandial Lipemia, Incretin Responses and Subclinical Inflammation in Obese Subjects

NCT ID: NCT00863564

Last Updated: 2009-11-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-03-31

Study Completion Date

2009-10-31

Brief Summary

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The purpose of this study is to determine the effects of dietary protein on blood lipids and gut hormones after a fat-rich meal.

Hypothesis: Certain dietary proteins reduce the amount of fat circulating in the blood stream following a fat rich meal. The effect is dependant of both the quality and the quantity of protein ingested.

Detailed Description

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Conditions

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Obesity Postprandial Lipemia Atherosclerosis Inflammation Postprandial Incretins

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Participants

Study Groups

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Whey Isolate

Group Type ACTIVE_COMPARATOR

Whey Isolate

Intervention Type DIETARY_SUPPLEMENT

Caseine

Group Type ACTIVE_COMPARATOR

Caseine

Intervention Type DIETARY_SUPPLEMENT

Cod

Group Type ACTIVE_COMPARATOR

Cod

Intervention Type DIETARY_SUPPLEMENT

Gluten

Group Type ACTIVE_COMPARATOR

Gluten

Intervention Type DIETARY_SUPPLEMENT

Interventions

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Caseine

Intervention Type DIETARY_SUPPLEMENT

Cod

Intervention Type DIETARY_SUPPLEMENT

Gluten

Intervention Type DIETARY_SUPPLEMENT

Whey Isolate

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* BMI \> 30 kg/m2 \& \< 45 kg/m2

Exclusion Criteria

* Diabetes
* Lipid lowering drugs
* Liver-, Kidney- and/or Heart Disease
* Serious Hypertension (160/110)
Minimum Eligible Age

40 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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The Danish Obesity Research Centre

OTHER

Sponsor Role collaborator

Nordic Centre of Excellence

OTHER

Sponsor Role collaborator

Aarhus University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Department of Endocrinology And Metabolism, Aarhus University Hospital

Principal Investigators

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K Hermansen, Professor, MD

Role: PRINCIPAL_INVESTIGATOR

Department of Endocrinology and Metabolism, Aarhus University Hospital

Locations

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Department of Clinical Nutrion

Aarhus, , Denmark

Site Status

Countries

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Denmark

References

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Holmer-Jensen J, Karhu T, Mortensen LS, Pedersen SB, Herzig KH, Hermansen K. Differential effects of dietary protein sources on postprandial low-grade inflammation after a single high fat meal in obese non-diabetic subjects. Nutr J. 2011 Oct 19;10:115. doi: 10.1186/1475-2891-10-115.

Reference Type DERIVED
PMID: 22011432 (View on PubMed)

Other Identifiers

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CERN-PPL-JHJ-5a

Identifier Type: -

Identifier Source: org_study_id

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