Influence of Protein Hydrolysis on Dietary Protein Digestibility and Metabolism in Healthy Subjects
NCT ID: NCT00873951
Last Updated: 2025-10-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
NA
26 participants
INTERVENTIONAL
2006-01-31
2008-01-31
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
The Effect of Hydrolyzed Casein on Energy Expenditure and Subjective Appetite
NCT01677273
Influence of Protein Source on Satiety and Metabolism
NCT00862329
Amino Acid Digestibility of Whey and Zein Proteins
NCT03279211
Effects of Dietary Proteins on Postprandial Lipaemia and Incretin Responses in Obese Subjects
NCT00809874
Effect of Intake of Hydrolyzed Krill Protein Isolate on Plasma Amino Acid Profile
NCT04864769
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
OTHER
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Intact casein
Subjects undergo an intestinal and metabolic exploration following the ingestion of a standard mixed meal containing 15% of energy as 15N-labelled intact casein
Intestinal and metabolic exploration
Subjects are studied for 8h following the ingestion of a standard meal containing 15% of energy as protein. Intestinal, blood and urine are collected at regular intervals.
15N-labelled intact casein
standard mixed meal containing 15% of energy as 15N-labelled intact casein
Hydrolyzed casein
Subjects undergo an intestinal and metabolic exploration following the ingestion of a standard mixed meal containing 15% of energy as 15N-labelled hydrolyzed casein
Intestinal and metabolic exploration
Subjects are studied for 8h following the ingestion of a standard meal containing 15% of energy as protein. Intestinal, blood and urine are collected at regular intervals.
15N-labelled hydrolyzed casein
standard mixed meal containing 15% of energy as 15N-labelled hydrolyzed casein
AA
Subjects undergo an intestinal and metabolic exploration following the ingestion of a standard mixed meal containing 15% of energy as a mixture of AA mimicking the composition of casein but devoid in serine
Intestinal and metabolic exploration
Subjects are studied for 8h following the ingestion of a standard meal containing 15% of energy as protein. Intestinal, blood and urine are collected at regular intervals.
mixture of AA
standard mixed meal containing 15% of energy as a mixture of AA mimicking the composition of casein but devoid in serine
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Intestinal and metabolic exploration
Subjects are studied for 8h following the ingestion of a standard meal containing 15% of energy as protein. Intestinal, blood and urine are collected at regular intervals.
15N-labelled intact casein
standard mixed meal containing 15% of energy as 15N-labelled intact casein
15N-labelled hydrolyzed casein
standard mixed meal containing 15% of energy as 15N-labelled hydrolyzed casein
mixture of AA
standard mixed meal containing 15% of energy as a mixture of AA mimicking the composition of casein but devoid in serine
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* BMI between 18 and 25
Exclusion Criteria
* positive serology to AgHbS, HCV or HIV
* pregnancy
* abusive drug or alcohol consumption.
18 Years
40 Years
ALL
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Riddet Institute
UNKNOWN
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Centre de recherche sur volontaires
Bobigny, , France
Countries
Review the countries where the study has at least one active or historical site.
References
Explore related publications, articles, or registry entries linked to this study.
Deglaire A, Moughan PJ, Airinei G, Benamouzig R, Tome D. Intact and hydrolyzed casein lead to similar ileal endogenous protein and amino acid flows in adult humans. Am J Clin Nutr. 2020 Jan 1;111(1):90-97. doi: 10.1093/ajcn/nqz268.
Deglaire A, Fromentin C, Fouillet H, Airinei G, Gaudichon C, Boutry C, Benamouzig R, Moughan PJ, Tome D, Bos C. Hydrolyzed dietary casein as compared with the intact protein reduces postprandial peripheral, but not whole-body, uptake of nitrogen in humans. Am J Clin Nutr. 2009 Oct;90(4):1011-22. doi: 10.3945/ajcn.2009.27548. Epub 2009 Aug 19.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
DEGLAIRE CT
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.