Influence of Protein Source on Satiety and Metabolism

NCT ID: NCT00862329

Last Updated: 2012-03-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-03-31

Study Completion Date

2010-11-30

Brief Summary

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Dietary protein is the more satiating nutrient, however it is not clear whether satiety may be influenced by the nature of the protein. This study was designed to assess potential differences between protein sources on satiety and their relationship with digestive and metabolic kinetics.

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Casein

Group Type EXPERIMENTAL

Casein-enriched diet

Intervention Type DIETARY_SUPPLEMENT

Subjects consume for 9 days a supplement of 30g/d of casein

MSP

Group Type EXPERIMENTAL

Milk soluble protein-enriched diet

Intervention Type DIETARY_SUPPLEMENT

Subjects consume for 9 days a supplement of 30g/d of milk soluble protein

Casein/MSP

Group Type EXPERIMENTAL

Casein and milk soluble proteins-enriched diet

Intervention Type DIETARY_SUPPLEMENT

Subjects consume for 9 days a supplement of 30g/d of a mix of casein and milk soluble protein

Soy protein

Group Type EXPERIMENTAL

Soy proteins-enriched diet

Intervention Type DIETARY_SUPPLEMENT

Subjects consume for 9 days a supplement of 30g/d of soy protein

Interventions

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Casein-enriched diet

Subjects consume for 9 days a supplement of 30g/d of casein

Intervention Type DIETARY_SUPPLEMENT

Milk soluble protein-enriched diet

Subjects consume for 9 days a supplement of 30g/d of milk soluble protein

Intervention Type DIETARY_SUPPLEMENT

Casein and milk soluble proteins-enriched diet

Subjects consume for 9 days a supplement of 30g/d of a mix of casein and milk soluble protein

Intervention Type DIETARY_SUPPLEMENT

Soy proteins-enriched diet

Subjects consume for 9 days a supplement of 30g/d of soy protein

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* BMI between 25 and 30

Exclusion Criteria

* allergy to milk proteins
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Research Agency, France

OTHER

Sponsor Role collaborator

Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

OTHER

Sponsor Role lead

Responsible Party

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Robert Benamouzig

Manager of the HNRC

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Centre de recherche sur volontaires

Bobigny, , France

Site Status

Countries

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France

References

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Marsset-Baglieri A, Fromentin G, Airinei G, Pedersen C, Leonil J, Piedcoq J, Remond D, Benamouzig R, Tome D, Gaudichon C. Milk protein fractions moderately extend the duration of satiety compared with carbohydrates independently of their digestive kinetics in overweight subjects. Br J Nutr. 2014 Aug 28;112(4):557-64. doi: 10.1017/S0007114514001470. Epub 2014 Jun 26.

Reference Type DERIVED
PMID: 24968280 (View on PubMed)

Boutrou R, Gaudichon C, Dupont D, Jardin J, Airinei G, Marsset-Baglieri A, Benamouzig R, Tome D, Leonil J. Sequential release of milk protein-derived bioactive peptides in the jejunum in healthy humans. Am J Clin Nutr. 2013 Jun;97(6):1314-23. doi: 10.3945/ajcn.112.055202. Epub 2013 Apr 10.

Reference Type DERIVED
PMID: 23576048 (View on PubMed)

Other Identifiers

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SURPROL

Identifier Type: -

Identifier Source: org_study_id

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