Differential Effects of Protein Quality on Postprandial Lipemia in Response to a Fat-Rich Meal in Type 2 Diabetes: Comparison of Whey, Casein, Gluten, and Cod Protein

NCT ID: NCT00817973

Last Updated: 2009-01-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Brief Summary

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Enhanced and prolonged postprandial triglyceride responses involve increased cardiovascular risk in type 2 diabetes. It has been demonstrated that dietary fat and carbohydrates profoundly influence postprandial hypertriglyceridemia in type 2 diabetes, whereas little information exists about the effect of proteins.

The purpose of this study is to compare the effects of the proteins casein, whey, cod, and gluten on postprandial lipid and incretin responses to a high-fat meal in type 2 diabetes.

Detailed Description

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Conditions

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Type 2 Diabetes Postprandial Lipemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Casein

Group Type ACTIVE_COMPARATOR

Casein

Intervention Type DIETARY_SUPPLEMENT

Whey

Group Type ACTIVE_COMPARATOR

Whey

Intervention Type DIETARY_SUPPLEMENT

Cod

Group Type ACTIVE_COMPARATOR

Cod

Intervention Type DIETARY_SUPPLEMENT

Gluten

Group Type ACTIVE_COMPARATOR

Gluten

Intervention Type DIETARY_SUPPLEMENT

Interventions

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Casein

Intervention Type DIETARY_SUPPLEMENT

Whey

Intervention Type DIETARY_SUPPLEMENT

Cod

Intervention Type DIETARY_SUPPLEMENT

Gluten

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Diabetes

Exclusion Criteria

* Liver, Kidney- and/or Heart Disease
* Serious Hypertension (160/110 mmHg)
Minimum Eligible Age

40 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The Danish Obesity Research Centre

OTHER

Sponsor Role collaborator

Nordic Centre of Excellence

OTHER

Sponsor Role collaborator

Aarhus University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Department of Endocrinology and Metabolism, Aarhus University Hospital

Principal Investigators

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Kjeld Hermansen, Professor, MD

Role: PRINCIPAL_INVESTIGATOR

Department of Endocrinology and Metabolism

Locations

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Department of Clinical Nutrition

Aarhus, , Denmark

Site Status

Countries

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Denmark

References

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Mortensen LS, Thomsen C, Hermansen K. Effects of different protein sources on plasminogen inhibitor-1 and factor VII coagulant activity added to a fat-rich meal in type 2 diabetes. Rev Diabet Stud. 2010 Fall;7(3):233-40. doi: 10.1900/RDS.2010.7.233. Epub 2010 Nov 10.

Reference Type DERIVED
PMID: 21409315 (View on PubMed)

Mortensen LS, Hartvigsen ML, Brader LJ, Astrup A, Schrezenmeir J, Holst JJ, Thomsen C, Hermansen K. Differential effects of protein quality on postprandial lipemia in response to a fat-rich meal in type 2 diabetes: comparison of whey, casein, gluten, and cod protein. Am J Clin Nutr. 2009 Jul;90(1):41-8. doi: 10.3945/ajcn.2008.27281. Epub 2009 May 20.

Reference Type DERIVED
PMID: 19458012 (View on PubMed)

Other Identifiers

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CERN-PPL (5A) LSM

Identifier Type: -

Identifier Source: org_study_id

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