A Study of Biochemical Response to Alternative Proteins
NCT ID: NCT06253728
Last Updated: 2024-02-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
24 participants
INTERVENTIONAL
2024-01-18
2025-12-31
Brief Summary
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Detailed Description
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1. To study the impact of complex plant- and animal-based foods on glucose metabolism, acute inflammation, and markers of microbial fermentation of fiber and proteins.
2. To investigate the difference in the gut mediated metabolism induced by naturally occurring fiber fraction bound plant protein or by plant protein with added fiber when compared to animal protein.
3. To conduct in vitro experiments using fecal samples from participants in the meal study to investigate the distinctions between different animal and plant proteins on both host and microbial metabolites, as well as the function of the gut barrier.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
PREVENTION
SINGLE
Study Groups
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Meal 1
Meal with plant protein and fiber in an intact structure
High fiber and protein meal
In the intervention participants are assigned to eat high protein and fiber meal that differ in protein source or structure.
Meal 2
Meal with plant protein and fiber, where the cell structure is broken
High fiber and protein meal
In the intervention participants are assigned to eat high protein and fiber meal that differ in protein source or structure.
Meal 3
Low protein and low fiber cereal
Control
The control meal is low fiber and low protein meal.
Meal 4
High protein and low carbohydrate bread with animal proteins
High fiber and protein meal
In the intervention participants are assigned to eat high protein and fiber meal that differ in protein source or structure.
Meal 5
High protein and low carbohydrate bread with plant protein
High fiber and protein meal
In the intervention participants are assigned to eat high protein and fiber meal that differ in protein source or structure.
Interventions
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High fiber and protein meal
In the intervention participants are assigned to eat high protein and fiber meal that differ in protein source or structure.
Control
The control meal is low fiber and low protein meal.
Eligibility Criteria
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Inclusion Criteria
* BMI \>25 kg/m2 and \<35 kg/m2
* Waist circumference with females \>85 cm and with males \>100 cm
Exclusion Criteria
* Pregnancy or breastfeeding
* Gluten-free or vegan diet
* Use of antibiotics within the last 12 months
* Gastrointestinal surgery within the last two years
* High alcohol consumption
30 Years
65 Years
ALL
No
Sponsors
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University of Eastern Finland
OTHER
Responsible Party
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Principal Investigators
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Marjukka Kolehmainen, Professor
Role: PRINCIPAL_INVESTIGATOR
University of Eastern Finland
Locations
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University of Eastern Finland
Kuopio, , Finland
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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A80406
Identifier Type: -
Identifier Source: org_study_id
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