Effects of Different Mode of Exercise Training on Type 2 Diabetes

NCT ID: NCT01000519

Last Updated: 2017-02-10

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2002-12-31
• Study Completion Date: 2006-06-30

Brief Summary

Randomized study on the comparison between aerobic training versus progressive resistance training over a 2 months period for older adults with type 2 diabetes. The hypothesis is that progressive resistance training is just as effective as aerobic training on Hba1c and could be an alternative training for those older diabetic patients who cannot participate in aerobic exercise.

Detailed Description

Many studies have shown the importance of aerobic training with respect to management of diabetes. However adoption of aerobic activities may be challenging for some individuals with diabetes, especially the elderly and the obese. There is increasing interest in resistance training and no study have looked at direct comparison between the two.

Subjects with diabetes but is generally sedentary (determined by means of a questionnaire) were recruited and randomized in one of the two groups. Subjects are supervised in a group and a completer is defined as one who completed 18 sessions within 8 weeks.

Conditions

Diabetes Mellitus, Type 2

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

Aerobic Training

50 minutes of aerobic training, 18 sessions within 2 months period

Group Type: ACTIVE_COMPARATOR

Aerobic Training

Intervention Type: OTHER

18 sessions over 2 months period. Each session consist of 50 minutes of aerobic training at 65-70 % of maximum predicted heart rate

Progressive Resistance Training

50 minutes of progressive resistance training consisting of nine resistance exercises, each conducted 3 sets of 10 repetitions. 18 sessions over 2 months period.

Group Type: EXPERIMENTAL

Progressive resistance training

Intervention Type: OTHER

18 sessions completed in 2 months. each session consists of 50 minutes of resistance training which is made up of 3 sets of 10 repetitions of nine resistive exercises using machines and free weights at 65-70% of 1-repetitive maximum.

Interventions

Aerobic Training

18 sessions over 2 months period. Each session consist of 50 minutes of aerobic training at 65-70 % of maximum predicted heart rate

Intervention Type: OTHER

Progressive resistance training

18 sessions completed in 2 months. each session consists of 50 minutes of resistance training which is made up of 3 sets of 10 repetitions of nine resistive exercises using machines and free weights at 65-70% of 1-repetitive maximum.

Intervention Type: OTHER

Other Intervention Names

Treadmill; Cross trainer; Cycling; Weight training; Circuit training

Eligibility Criteria

Inclusion Criteria

• aged 50 years and above,
• Hba1c between 8 to 10 % in the past one month,
• sedentary,
• able to continuously walk for at least 20 minutes and climbed one flight of stairs unaided without stopping were eligible for participation.

Exclusion Criteria

• uncontrolled diabetes mellitus with Hba1c more than 10% or if escalation of treatment of glycemic control or dyslipidemia was likely to be necessary over the 2 months training period period,
• congestive cardiac failure, unstable angina or acute myocardial infarction within the last one year,
• proliferative diabetic retinopathy,
• uncontrolled hypertension,
• advanced arthritis likely to limit mobility or participation in prescribed exercises,
• respiratory conditions such as asthma and chronic obstructive lung disease,
• significant proteinuria or chronic renal insufficiency,
• received drugs for the treatment of obesity or very low caloric diet (VLCD, less than 1000 kcal/ day),
• renal disease and
• inability to monitor glucose level or comply with exercise program.

• Minimum Eligible Age: 50 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Singapore General Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Li Whye Cindy Ng

Role: PRINCIPAL_INVESTIGATOR

Singapore General Hospital

Locations

Singapore General Hospital

Singapore, , Singapore

Countries

Singapore

References

Boule NG, Haddad E, Kenny GP, Wells GA, Sigal RJ. Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials. JAMA. 2001 Sep 12;286(10):1218-27. doi: 10.1001/jama.286.10.1218.

Reference Type: BACKGROUND

PMID: 11559268 (View on PubMed)

Arora E, Shenoy S, Sandhu JS. Effects of resistance training on metabolic profile of adults with type 2 diabetes. Indian J Med Res. 2009 May;129(5):515-9.

Reference Type: BACKGROUND

PMID: 19675378 (View on PubMed)

Ng CL, Tai ES, Goh SY, Wee HL. Health status of older adults with Type 2 diabetes mellitus after aerobic or resistance training: a randomised trial. Health Qual Life Outcomes. 2011 Aug 2;9:59. doi: 10.1186/1477-7525-9-59.

Reference Type: DERIVED

PMID: 21810269 (View on PubMed)

Ng CL, Goh SY, Malhotra R, Ostbye T, Tai ES. Minimal difference between aerobic and progressive resistance exercise on metabolic profile and fitness in older adults with diabetes mellitus: a randomised trial. J Physiother. 2010;56(3):163-70. doi: 10.1016/s1836-9553(10)70021-7.

Reference Type: DERIVED

PMID: 20795922 (View on PubMed)

Other Identifiers

NMRC/0728/2003

Identifier Type: -

Identifier Source: org_study_id