Effect of Aerobic Training Versus Resistance Training on Plasma Homocystiene in Diabetic Patients

NCT ID: NCT05845190

Last Updated: 2023-05-06

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-04-04
• Study Completion Date: 2023-05-15

Brief Summary

The goal of this [clinical trial] is to [ compare ] in [ diabetic male patients ]. The main question to answer is :

Will be any difference between aerobic exercises and resistance exercises in improving levels of homocysteine, cholesterol and insulin in diabetic patients?

Participants will take their medications and group of them do aerobic exercises and another group do resistance training

Detailed Description

40 male diabetic patients diagnosed by type 2 diabetes mellites to evaluate therapeutics outcomes of aerobic exercises versus resistance exercises as a treatment tool on homocysteine, insulin and cholesterol levels in diabetic patients.

The patients will be randomly assigned to two equal (in number) groups:

Group (A) Twenty male patients will receive moderate intensity aerobic exercises in a form of supervised treadmill walking for 30-45 mins performed 3 times/ week for 12 weeks.

Group (B) Twenty male patients will receive resistance training program comprised 30-45 min performed 3 times /week for 12 weeks.

Conditions

Diabete Type 2

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

aerobic exercises group (group A )

20 male patients with diabetes mellites Attended the program of walking on treadmill for 12 weeks according to the following parameters.

Exercise prescription:

Intensity: started by 60-75% of target heart rate according to each patient response.

Duration: Each session consisted of five minutes warming up firstly then 25-30 minutes time of session ended by five minutes cool down exercises Frequency: Three times / week (day after day) for 12 weeks

Group Type: EXPERIMENTAL

aerobic exercises

Intervention Type: OTHER

aerobic exercises in form of walking on treadmill

resistance exercises group (group B)

20 male patients with diabetes mellites will participate in resistance training exercises 30-45 mins. The subject will warm up and cool down for at least five to seven minutes each, (before and after exercise) with initial load of 60% of 1 repetition maximum.

This program consists of 3 sets of 8 to 12 repetitions, then increasing load when subject was able to complete 12 repetitions. A rest period of 1.5 min was established between each set.

Mode: 4 upper body exercises (bench press, seated row, shoulder press, and pull down), 3 leg exercises (leg press, extension, and flexion), abdominal crunches and back extensions. with the individualized workloads at 60% of 1RM.

Duration: 30 min-45 min (total session). Frequency: Three times / week (day after day). Intensity: increased load was established when subject was able to complete 12 repetitions.

Group Type: EXPERIMENTAL

resistance exercises

Intervention Type: OTHER

60% of One-repetition maximum 3 sets ( 8 to 12 ) repetitions

Interventions

aerobic exercises

aerobic exercises in form of walking on treadmill

Intervention Type: OTHER

resistance exercises

60% of One-repetition maximum 3 sets ( 8 to 12 ) repetitions

Intervention Type: OTHER

Other Intervention Names

group A; group B

Eligibility Criteria

Inclusion Criteria

• 1- Their ages will range from 40 -55 years 2- Their body mass indexes will range between (25 to 35 Kg / m²). 3-All patients are diagnosed with type 2 diabetes mellites.
• Diagnostic criteria for type 2 diabetes were: 1) a fasting plasma glucose concentration of 7.0 mmol·L-1 or higher or 2) a plasma glucose concentration of 11.1 mmol·L-1 or higher two hours after an oral glucose challenge. (Punthakee et al.,2018).
• All subjects took oral hypoglycemic drugs but none of them were being treated with insulin when enrolled.

4- All patients are medically and psychologically stable

Exclusion Criteria

1. Patients with uncontrolled blood glucose level

2. Patients with unstable cardiovascular conditions (those with a known history of uncontrolled hypertension, ischemic attacks, stroke, congestive heart failure, currently on anticoagulation therapy) were excluded from this study.

3. Patients with severe pulmonary disease (with restrictive lung disease or with obstructive lung disease).

4. Patients with musculoskeletal disorders (Diagnosed with severe osteoporosis or severe osteoarthritis).

5. Patients with BMI > 35 will be excluded from the study.

• Minimum Eligible Age: 40 Years
• Maximum Eligible Age: 55 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: No

Sponsors

Egyptian Chinese University

OTHER

Sponsor Role: lead

Responsible Party

hanan hassan

Assistant lecturer

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

hanan hassan

Role: PRINCIPAL_INVESTIGATOR

Egyptian Chinese University

Locations

Egyptian Chineese University

Cairo, Gesr Elsuez, Egypt

Countries

Egypt

Other Identifiers

P.T.REC/012/003654

Identifier Type: -

Identifier Source: org_study_id