Effect of Alter-G Training on Glycemic Control and Quality of Life in Diabetic Neuropathy
NCT ID: NCT05115747
Last Updated: 2023-12-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
80 participants
INTERVENTIONAL
2021-01-15
2021-10-20
Brief Summary
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Detailed Description
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Lower extremity aerobic exercise training (e.g., walking, treadmill and bicycle ergometer) is a good procedure to control and disrupt the progression of hyperglycemia in elderly with DPN. Furthermore; it improves lower limb muscle oxygen uptake, enhances the nerve conduction and proprioceptors sensitivity during activities. Lowe extremity aerobic exercise training can enhance balance, thereby reducing the falling risk. Aerobic exercise is also helpful in preventing age related lifestyle disease and improving quality of life (QOL) of the elderly. A conflict was clearly evoked between prescribing weight bearing and non- weight bearing exercise for elderly with diabetic polyneuropathy.
Weight bearing theoretical basis assumes that weight bearing activities such as walking are superior to other non- weight- bearing activities because of its ability to promote and restore muscular strength, joint proprioception and range of motion necessary to effectively perform typical daily activities. Although weight bearing training can significantly improve walking and balance abilities in patients with diabetic polyneuropathy compared with non- weight bearing training, but there were still not enough evidences to prove the ideal percentage level of weight reduction or unloading during practicing lower extremity training exercise in elderly with diabetic polyneuropathy. Quite recently, a new antigravity treadmill based on The National Aeronautics and Space Administration (NASA) technology was introduced. It permits low- load walking using an emerging technology called lower body positive pressure (LBPP) to modify body weight during ambulation. Few trials handled the utilization of LBPP technology and further trials are still warranted to to develop a more effective conservative and intervention treatment protocol for enhancing physical activities, quality of life and functional performance in elderly patients with diabetic polyneuropathy.
Conditions
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Keywords
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Study Design
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RANDOMIZED
FACTORIAL
Participants in the study groups received twelve-weeks mild to moderate intensity aerobic training program on the Alter-G anti-gravity treadmill.
The Glycemic control (Fasting blood glucose in mg/dl, glycated hemoglobin, and health-related quality of life were evaluated at three time points: at the beginning of the study, after three months aerobic exercise training and three months post-training cessation.
TREATMENT
DOUBLE
* Participants' random allocation was conducted by an independent person. The participants were unaware of the percentage of weight off-loading during the treadmill aerobic exercise training.
* Outcomes Assessor kept blind about the group's allocation and the applied exercise training protocols.
Study Groups
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"Zero percentage" weight off-loading group-A
This group received the Mild to moderate aerobic exercise training on the Alter-G treadmill with the full weight-bearing for three months.
weight off-loading aerobic exercise training.
Mild to moderate intensity weight off-loading aerobic exercise training on the anti-gravity Alter-G treadmill. (speed 8-12 mph, 50%-70% heart rate reserve "HRR", 12-16 score on the Borg's scale)
"Twenty-five percentage" weight off-loading group-B
This group received the Mild to moderate aerobic exercise training on the Alter-G treadmill with the twenty-five percentage" weight off-loading for three months.
weight off-loading aerobic exercise training.
Mild to moderate intensity weight off-loading aerobic exercise training on the anti-gravity Alter-G treadmill. (speed 8-12 mph, 50%-70% heart rate reserve "HRR", 12-16 score on the Borg's scale)
"Fifty percentage" weight off-loading group-C
This group received the Mild to moderate aerobic exercise training on the Alter-G treadmill with the fifty percentage" weight off-loading for three months.
weight off-loading aerobic exercise training.
Mild to moderate intensity weight off-loading aerobic exercise training on the anti-gravity Alter-G treadmill. (speed 8-12 mph, 50%-70% heart rate reserve "HRR", 12-16 score on the Borg's scale)
"Seventy-five percentage" weight off-loading group-D
This group received the Mild to moderate aerobic exercise training on the Alter-G treadmill with the seventy-five percentage" weight off-loading for three months.
weight off-loading aerobic exercise training.
Mild to moderate intensity weight off-loading aerobic exercise training on the anti-gravity Alter-G treadmill. (speed 8-12 mph, 50%-70% heart rate reserve "HRR", 12-16 score on the Borg's scale)
Control group-E
Participated no aerobic exercise training.
No interventions assigned to this group
Interventions
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weight off-loading aerobic exercise training.
Mild to moderate intensity weight off-loading aerobic exercise training on the anti-gravity Alter-G treadmill. (speed 8-12 mph, 50%-70% heart rate reserve "HRR", 12-16 score on the Borg's scale)
Eligibility Criteria
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Inclusion Criteria
* Diagnosed as having uncontrolled type 2 diabetes mellitus, with glycosylated hemoglobin (HbA1c) value between 7 and 11 and fasting glucose level ranged from 7.0 -11.1 mmol/L,
* Age range from 60 and 80 years old,
* Established type 2 diabetes mellitus duration over 10 years, treated only with oral anti-diabetic agents (not taking insulin), treated only with Biguanide alone or (Sulfonylureas plus Biguanide) oral anti-diabetic drugs combination, with pharmacological treatment had to be stable for at least 3 months before the study,
* Cognitively competent and able to understand and follow instructions, capable of rationally interacting with others; understanding and answering the health related quality of life questionnaire (HRQL).
Exclusion Criteria
* Younger than 60 or older than 80 years old,
* Patient with malnutrition (BMI \< 21 kg/m2 or with recent weight loss \> 5% body weight in the last month or \> 10% in six months),
* Patients with established hypertension (resting systolic blood pressure \> 140 mmHg and diastolic blood pressure \> 90 mmHg,
* Active infection, drug abuse, participated in to an active rehabilitation program within last 6 months,
* With severe chronic or uncontrolled comorbid condition as recent myocardial infarction, unstable angina, acute congestive heart failure, third degree heart block and uncontrolled arrhythmia.
* With abnormal skin integrity e.g. wound or scares tissues or are on other complementary treatment,
* History of serious cerebrovascular or cardiovascular diseases, and severe debilitating musculoskeletal problems) that could interfere with the evaluation or treatment efficacy and patient safety or precluded the patient from attending and completing the treatment sessions.
60 Years
80 Years
ALL
No
Sponsors
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King AbdulAziz City for Science and Technology
OTHER
Umm Al-Qura University
OTHER
Responsible Party
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Ashraf Abdelaal
ASSOCIATE PROFESSOR
Principal Investigators
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ASHRAF AM ABDELAAL
Role: PRINCIPAL_INVESTIGATOR
Umm Al-Qura University
Locations
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Umm Al-Qura University
Mecca, , Saudi Arabia
Countries
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Other Identifiers
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Umm AlQura Un
Identifier Type: -
Identifier Source: org_study_id